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ABC-AF Bleeding ScoreABC-AF Stroke ScoreABCD2 ScoreADD-RSAortic Valve Calcium ScoreAPPLE ScoreASCVD (Pooled Cohort)AVA (Continuity Equation)BAG-AHF ScoreBiplane Simpson EFBlood Pressure PercentilesBrugada Criteria (VT vs SVT)Cardiac Output IndexCHA2DS2-VAScCHADS2Cornell Voltage CriteriaCRUSADE Bleeding ScoreDAPT ScoreDASIDuke Treadmill ScoreE/A RatioEDACS ScoreEHMRGEHRA ScoreEmbolic Risk ScoreEROA (PISA Method)EuroSCORE IIFFR (Fractional Flow Reserve)Fick Cardiac OutputFramingham 10-Year RiskFriedewald LDL EquationGorlin EquationGRACE ScoreGupta MICA (NSQIP)GWTG-HF ScoreH2FPEF ScoreHakki FormulaHAS-BLEDHEART PathwayHEART ScoreHEMORR2HAGEShs-Troponin 0h/1h ESC AlgorithmiFRINTERCHEST ScoreKillip ClassificationLee's RCRILV Mass IndexLV Stroke Work IndexMAGGIC Risk ScoreMAP CalculatorMartin/Hopkins LDLModified Duke CriteriaModified Sgarbossa CriteriaMVA (Pressure Half-Time)Non-HDL CholesterolNT-proBNP Age-Adjusted ThresholdsORBIT ScoreOttawa Heart Failure RiskPulse PressurePVR CalculatorPVR IndexQRISK3QTc (Bazett)QTc (Fridericia)REVEAL 2.0 ScoreReynolds Risk ScoreROSIRVSP CalculatorSchwartz Score (LQTS)SCORE2Seattle Heart Failure Model (SHFM)Sgarbossa CriteriaShock IndexSokolow-Lyon VoltageStroke Volume IndexSVR CalculatorSYNTAX ScoreSYNTAX Score IITAPSETeichholz FormulaTIMI (STEMI)TIMI (UA/NSTEMI)Troponin Delta CalculatorValvular GradientsVancouver Chest Pain RuleVereckei AlgorithmWATCHDM ScoreWilkins ScoreWood Units Calculator

Clinical Evidence and Methodology

EVIDENCE SYNTHESIS

Clinical Reference Hub

Curated insights • How it Works • Practical Pearls • Evidence Base

CLINICAL INSIGHT

When to Use

When to Use

  • Quantification of aortic stenosis severity on TTE/TEE
  • Decision-making for AVR vs. conservative management
  • Diagnostic workup of murmurs
  • Serial assessment of severe AS progression
  • Discordant gradient/area findings (low-flow states)

Key Points

  • Recommended by ACC/AHA and ESC guidelines as gold standard for AS quantification
  • More reliable than simpler planimetered area in off-axis imaging
  • Critical in low-gradient AS scenarios for true area determination
  • Requires good image quality (LVOT visualization + aortic valve alignment)
CLINICAL INSIGHT

How it Works

Formula

Severity Classification (Aortic Stenosis)

AVA (cm2)Mean Gradient (mmHg)Classification
>1.5<25Mild
1.0–1.525–40Moderate
<1.0>40Severe
<0.6VariableVery Severe (operative threshold)
CLINICAL INSIGHT

Practical Pearls

Technical Considerations

  • LVOT diameter must be measured in systole at base of anterior mitral leaflet
  • Undersizing LVOT diameter → underestimates AVA; oversizing → overestimates
  • Off-axis CWD recording at aortic valve → artificially elevated velocities → artificially reduced AVA
  • VTI should be traced from the same cardiac cycle on both LVOT (PWD) and AV (CWD)

Clinical Pearls

  • In low-flow/low-gradient AS (LVOL EF, small LV), continuity equation AVA best reflects true anatomy
  • Indexed AVA (AVA / BSA) helps distinguish true severe AS in small-bodied patients
  • Discordance between continuity AVA and planimetry → TEE for clarification
  • Serial AVA >0.1 cm2/year decline signals rapid progression; consider earlier AVR
CLINICAL INSIGHT

Next Steps

Mild AS (AVA >1.5 cm2)

  • Reinforce endocarditis prophylaxis and lifestyle modification
  • 3–5 year echo surveillance
  • No restriction on activity in asymptomatic patients
  • Annual cardiology follow-up if additional risk factors

Moderate AS (AVA 1.0–1.5 cm2)

  • Annual TTE with symptom inquiry
  • Consider stress echo if symptoms equivocal
  • Monitor for other valve disease, LV dysfunction
  • Reinforce activity modification if symptoms develop

Severe AS (AVA <1.0 cm2)

  • Refer for cardiothoracic surgery evaluation
  • Symptomatic patients = surgical candidate (SAVR or TAVR)
  • Asymptomatic with LV EF drop, rapid progression, or low gradient → consider AVR regardless
  • Stress testing may be warranted if symptoms unclear and AVA borderline

Complementary Calculators

CLINICAL INSIGHT

Evidence Base

Validation

ESC/EACTS Guidelines for the management of valvular heart disease.

Baumgartner H, et al.EuroIntervention.2017

2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease.

Nishimura RA, et al.Circulation.2014

AVA (Continuity Equation)

AVA (Continuity Equation): Calculates aortic valve area from Doppler echocardiography to assess aortic stenosis severity.

cm
cm
cm
m2

Formula

AVA = (π/4 × LVOT d2) × (VTILVOT / VTIAV)

No clinical reference data available.