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Clinical Evidence and Methodology

EVIDENCE SYNTHESIS

Clinical Reference Hub

Curated insights • How it Works • Practical Pearls • Evidence Base

CLINICAL INSIGHT

When to Use

When to Use

  • Prognostic assessment of patients with chronic heart failure (both HFrEF and HFpEF).
  • To guide clinical decision-making regarding advanced therapies, including referral for heart transplantation or Left Ventricular Assist Device (LVAD) evaluation.
  • To demonstrate the potential survival benefit of guideline-directed medical therapy (GDMT) to patients.
CLINICAL INSIGHT

How it Works

Model Overview

The SHFM is a multivariable Cox proportional hazards model derived from several prospective randomized trials. It incorporates 24 variables to estimate the hazard ratio and absolute survival probability over 1, 2, and 5 years.

Key Predictors

  • Demographics: Age and Sex.
  • Functional Status: NYHA Class and Ischemic vs. Non-ischemic etiology.
  • Physiology: LVEF and Systolic BP.
  • Labs: Sodium, Hemoglobin, Percent Lymphocytes, and Uric Acid.
  • Meds: Doses of diuretics, and presence of ACEi/ARB, Beta-blockers, and Statins.
  • Devices: Implantation of ICD or CRT.
CLINICAL INSIGHT

Practical Pearls

The Vicious Cycle of Diuretics

The model notably high-weights the dose of loop diuretics. While diuretics are necessary for symptom management, high doses are often markers of advanced refractory disease and neurohormonal activation, contributing strongly to the predicted hazard.

Shared Decision Making

The SHFM is uniquely suited for patient counseling. By toggling "protective" entries like ACEi or BB, a clinician can show a patient the projected "years of life gained" by adherence to GDMT.

CLINICAL INSIGHT

Evidence Base

Original Derivation

The Seattle Heart Failure Model: prediction of survival in heart failure.

Levy WC, Mozaffarian D, Linker DT, et al.Circulation.2006

Validation of the Seattle Heart Failure Model in a modern heart failure cohort.

Kochi AN, Kochi AM, Zelniker TA, et al.ESC Heart Fail.2021

Seattle Heart Failure Model (SHFM)

Seattle Heart Failure Model: Multivariable tool to predict survival in heart failure. Incorporates labs, meds, and devices.

Demographics & NYHA

Vital Labs

Therapies

No clinical reference data available.