Revised Amsterdam IIHereditary Non-Polyposis Colorectal CancerPatient ExplanationFamilial Clusters≥ 3 Relatives affectedCRC, Endometrium, Small Bowel, or Ureter/PelvisFirst-degree connectionOne relative is 1st-degree to the other two≥ 2 Successive GenerationsEvidence of horizontal/vertical transmission≥ 1 Diagnosed < 50yAt least one cancer diagnosis before age 50FAP ExcludedFamilial Adenomatous Polyposis not presentPathology VerifiedTumors verified by pathological examinationCheck Criteria MatchMolecular ScreeningAssess the "3-2-1" rule to determine if the family tree suggestive of hereditary colorectal cancer syndromes.