Clinical Pharmacology

Therapeutic drug monitoring (TDM) is essential for drugs with narrow therapeutic indices. Vancomycin AUC/MIC-guided dosing (target 400-600 mg*h/L for serious MRSA infections) has replaced traditional trough-only monitoring per the 2020 consensus guidelines. Aminoglycoside once-daily dosing uses Hartford nomogram-based extended-interval monitoring.

Renal dose adjustment follows FDA-approved prescribing information and KDIGO guidelines, with calculated eGFR (CKD-EPI 2021) determining dose intervals and maximum doses for renally cleared medications. Our calculators automate the adjustment process for over 50 commonly prescribed medications requiring renal dose modification.

Warfarin dosing is guided by pharmacogenetic algorithms incorporating CYP2C9 and VKORC1 genotype, along with clinical factors including age, BMI, and target INR. Direct oral anticoagulant (DOAC) dose adjustment calculators ensure appropriate dosing based on renal function, weight, and drug interactions per FDA labeling.