AMINOACETIC ACID 1.5% IN PLASTIC CONTAINER
Clinical safety rating: caution
Comprehensive clinical and safety monograph for AMINOACETIC ACID 1.5% IN PLASTIC CONTAINER (AMINOACETIC ACID 1.5% IN PLASTIC CONTAINER).
Aminoacetic acid (glycine) acts as an inhibitory neurotransmitter in the central nervous system and is involved in various metabolic processes. As a 1.5% solution in plastic container, it provides free amino acid for parenteral nutrition, contributing to protein synthesis and maintenance of nitrogen balance.
| Metabolism | Aminoacetic acid is primarily metabolized via the glycine cleavage system in the liver and kidneys. It can also be converted to serine by serine hydroxymethyltransferase. |
| Excretion | Renal: >95% unchanged; tubular reabsorption is minimal. Biliary/fecal: <5%. |
| Half-life | 1-2 hours; prolonged in renal impairment (up to 8-10 hours if GFR <30 mL/min). |
| Protein binding | <5% (primarily albumin). |
| Volume of Distribution | 0.4-0.6 L/kg; distributes mainly in extracellular fluid. |
| Bioavailability | Oral: approximately 100% (small molecule, complete absorption via carrier-mediated transport). |
| Onset of Action | Intravenous: within 5-10 minutes; oral: 30-60 minutes. |
| Duration of Action | Intravenous: 1-2 hours; oral: 2-4 hours; clinical effect correlates with plasma levels. |
Intravenous infusion of 1.5% aminoacetic acid solution. Typical adult dose: 500 mL to 1000 mL infused over 2 to 4 hours as needed, based on clinical response and electrolyte balance.
| Dosage form | SOLUTION |
| Renal impairment | Contraindicated in patients with severe renal impairment (GFR < 30 mL/min) due to risk of fluid overload and electrolyte disturbances. In moderate impairment (GFR 30-60 mL/min), reduce infusion rate by 50% and monitor serum electrolytes and volume status. |
| Liver impairment | No specific dose adjustment for Child-Pugh class A or B. In Child-Pugh class C, use with caution: consider reducing infusion rate and monitoring for signs of hepatic encephalopathy exacerbation. |
| Pediatric use | Weight-based dosing: 2-4 mL/kg per dose as a continuous infusion over 2 hours, not to exceed 100 mL per dose. Adjust based on age and clinical response; monitor fluid balance. |
| Geriatric use | In elderly patients, use lower initial infusion rates (e.g., 250 mL over 4 hours) due to reduced renal function and increased risk fluid overload. Monitor electrolytes and volume status closely. |
| 1st trimester | Consult provider |
| 2nd trimester | Consult provider |
| 3rd trimester | Consult provider |
Clinical note
Comprehensive clinical and safety monograph for AMINOACETIC ACID 1.5% IN PLASTIC CONTAINER (AMINOACETIC ACID 1.5% IN PLASTIC CONTAINER).
| Breastfeeding | Glycine is a normal constituent of breast milk. M/P ratio not determined. Considered compatible with breastfeeding at this low concentration. |
| Teratogenic Risk | Aminoacetic acid (glycine) 1.5% is not associated with teratogenic risk. Usual doses do not increase risk of major birth defects. First trimester: no evidence of fetal harm. Second/third trimesters: no reported adverse fetal effects. |
| Fetal Monitoring |
■ FDA Black Box Warning
No FDA black box warning is specifically associated with aminoacetic acid 1.5% in plastic container.
| Serious Effects |
["Hypersensitivity to aminoacetic acid or any component of the formulation.","Severe hepatic failure with risk of hyperammonemia.","Pre-existing metabolic acidosis or severe electrolyte imbalances (relative contraindication).","Use in patients with maple syrup urine disease or other disorders of amino acid metabolism (relative)."]
| Precautions | ["Monitor serum electrolyte levels, acid-base balance, and liver function during prolonged use.","Use with caution in patients with renal impairment due to risk of fluid overload or electrolyte disturbances.","Hypersensitivity reactions may occur (rare)."] |
| Food/Dietary | No known food interactions. Use as directed by healthcare provider. |
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| No specific monitoring required beyond standard obstetrical care. Monitor maternal serum electrolytes if large volumes infused. |
| Fertility Effects | No known adverse effects on fertility at therapeutic doses. |
| Clinical Pearls | Aminoacetic acid 1.5% in plastic container is an irrigation solution used for urologic procedures. It is iso-osmotic and non-electrolyte, reducing risk of hemolysis and electrolyte disturbances during transurethral resection. Monitor for fluid overload in patients with renal impairment. |
| Patient Advice | This solution is for irrigation only, not for injection or ingestion. · Report any signs of fluid overload, such as shortness of breath or swelling. · Inform your healthcare provider if you have kidney problems or heart failure. |