Therapeutic Classification

antagonist Registry

Clinical reference for antagonist medications. Access safety monographs, dosing adjustments, and drug-drug interactions for all registered brand names and generics in this class.

Registered Medications (antagonist)

Medication	Therapeutic Class	Maternal Safety
ACCOLATE Comprehensive clinical and safety monograph for ACCOLATE (ACCOLATE).	Leukotriene Receptor Antagonist	caution
ACETAMINOPHEN AND PENTAZOCINE HYDROCHLORIDE CNS depressants may enhance sedative effects Can cause withdrawal in patients dependent on other opioids.	Opioid Agonist-Antagonist	safe
ACTEMRA Comprehensive clinical and safety monograph for ACTEMRA (ACTEMRA).	IL-6 Receptor Antagonist	caution
ADBRY Comprehensive clinical and safety monograph for ADBRY (ADBRY).	Interleukin-13 Antagonist	caution
AIMOVIG Comprehensive clinical and safety monograph for AIMOVIG (AIMOVIG).	CGRP Antagonist	caution
AJOVY Comprehensive clinical and safety monograph for AJOVY (AJOVY).	CGRP Antagonist	caution
AKTEN Comprehensive clinical and safety monograph for AKTEN (AKTEN).	LFA-1 Antagonist (Ophthalmic)	caution
ALOSETRON HYDROCHLORIDE Comprehensive clinical and safety monograph for ALOSETRON HYDROCHLORIDE (ALOSETRON HYDROCHLORIDE).	5-HT3 Antagonist	caution
ALOXI Comprehensive clinical and safety monograph for ALOXI (ALOXI).	5-HT3 Antagonist	caution
ALVIMOPAN Comprehensive clinical and safety monograph for ALVIMOPAN (ALVIMOPAN).	Peripherally Acting Mu-Opioid Receptor Antagonist	caution
AMBRISENTAN Comprehensive clinical and safety monograph for AMBRISENTAN (AMBRISENTAN).	Endothelin Receptor Antagonist	caution
ANTAGONATE Comprehensive clinical and safety monograph for ANTAGONATE (ANTAGONATE).	Gonadotropin-Releasing Hormone Antagonist	caution
ANZEMET Comprehensive clinical and safety monograph for ANZEMET (ANZEMET).	Antiemetic (5-HT3 Antagonist)	caution
ASCLERA Comprehensive clinical and safety monograph for ASCLERA (ASCLERA).	Endothelin Receptor Antagonist	caution
AXID Comprehensive clinical and safety monograph for AXID (AXID).	H2 Receptor Antagonist	caution
AXID AR Comprehensive clinical and safety monograph for AXID AR (AXID AR).	H2 Receptor Antagonist	caution
BELSOMRA Comprehensive clinical and safety monograph for BELSOMRA (BELSOMRA).	Orexin Receptor Antagonist	caution
BOSENTAN Strong CYP3A4 inducers like rifampin decrease levels and inhibitors like ketoconazole increase levels Requires monthly monitoring of liver enzymes due to risk of hepatotoxicity.	Endothelin Receptor Antagonist	avoid
BUPRENORPHINE HYDROCHLORIDE AND NALOXONE HYDROCHLORIDE No significant drug interactions Can precipitate acute withdrawal in patients dependent on opioids.	Opioid Antagonist	safe
BUPRENORPHINE HYDROCHLORIDE; NALOXONE HYDROCHLORIDE No significant drug interactions Can precipitate acute withdrawal in patients dependent on opioids.	Opioid Antagonist	safe
CETRORELIX ACETATE Comprehensive clinical and safety monograph for CETRORELIX ACETATE (CETRORELIX ACETATE).	GnRH antagonist	caution
CETROTIDE Comprehensive clinical and safety monograph for CETROTIDE (CETROTIDE).	GnRH antagonist	caution
CIMDUO Comprehensive clinical and safety monograph for CIMDUO (CIMDUO).	H2 Receptor Antagonist Combination	caution
CINVANTI Comprehensive clinical and safety monograph for CINVANTI (CINVANTI).	Substance P/Neurokinin 1 Receptor Antagonist (Antiemetic)	caution
DARTISLA ODT Comprehensive clinical and safety monograph for DARTISLA ODT (DARTISLA ODT).	Adenosine A2A Receptor Antagonist	caution
DAYVIGO Comprehensive clinical and safety monograph for DAYVIGO (DAYVIGO).	Orexin Receptor Antagonist	caution
DECAPRYN Comprehensive clinical and safety monograph for DECAPRYN (DECAPRYN).	Antihistamine (H1 Receptor Antagonist)	caution
DEGARELIX ACETATE Comprehensive clinical and safety monograph for DEGARELIX ACETATE (DEGARELIX ACETATE).	GnRH antagonist	caution
DUEXIS Comprehensive clinical and safety monograph for DUEXIS (DUEXIS).	NSAID/H2 Antagonist Combination	caution
DUPIXENT Comprehensive clinical and safety monograph for DUPIXENT (DUPIXENT).	Interleukin-4 Receptor Alpha Antagonist	caution
ELAGOLIX Comprehensive clinical and safety monograph for ELAGOLIX (ELAGOLIX).	Gonadotropin-Releasing Hormone Antagonist	caution
ENSPRYNG Comprehensive clinical and safety monograph for ENSPRYNG (ENSPRYNG).	Interleukin-6 Receptor Antagonist	caution
ENTEREG Comprehensive clinical and safety monograph for ENTEREG (ENTEREG).	Peripheral Opioid Antagonist	caution
ENTYVIO Comprehensive clinical and safety monograph for ENTYVIO (ENTYVIO).	Monoclonal Antibody Integrin Antagonist	caution
EPLERENONE Strong CYP3A4 inhibitors (eg ketoconazole) are contraindicated Can cause hyperkalemia particularly in patients with renal impairment.	Aldosterone Antagonist	caution
EVZIO Comprehensive clinical and safety monograph for EVZIO (EVZIO).	Opioid Antagonist	caution
EVZIO (AUTOINJECTOR) Comprehensive clinical and safety monograph for EVZIO (AUTOINJECTOR) (EVZIO (AUTOINJECTOR)).	Opioid Antagonist	caution
FASLODEX Comprehensive clinical and safety monograph for FASLODEX (FASLODEX).	Estrogen Receptor Antagonist	caution
FILSPARI Comprehensive clinical and safety monograph for FILSPARI (FILSPARI).	Endothelin Receptor Antagonist / ARB	caution
FIRAZYR Comprehensive clinical and safety monograph for FIRAZYR (FIRAZYR).	Bradykinin B2 Receptor Antagonist	caution
FIRMAGON Comprehensive clinical and safety monograph for FIRMAGON (FIRMAGON).	GnRH Antagonist	caution
FLUMAZENIL Can precipitate acute withdrawal in patients dependent on benzodiazepines Seizures may occur especially in patients on long-term benzodiazepines.	Benzodiazepine Antagonist	safe
FULVESTRANT No significant drug interactions Can cause injection site reactions and nausea.	Estrogen Receptor Antagonist	avoid
GANIRELIX ACETATE Comprehensive clinical and safety monograph for GANIRELIX ACETATE (GANIRELIX ACETATE).	Gonadotropin-Releasing Hormone Antagonist	caution
GRANISETRON HYDROCHLORIDE No significant drug interactions Generally well-tolerated with headache being the most common side effect.	5-HT3 Antagonist	safe
GRANISETRON HYDROCHLORIDE PRESERVATIVE FREE No significant drug interactions Generally well-tolerated with headache being the most common side effect.	5-HT3 Antagonist	safe
GRANISOL Comprehensive clinical and safety monograph for GRANISOL (GRANISOL).	5-HT3 Receptor Antagonist	caution
ICATIBANT ACETATE Comprehensive clinical and safety monograph for ICATIBANT ACETATE (ICATIBANT ACETATE).	Bradykinin B2 Receptor Antagonist	caution
INSPRA Comprehensive clinical and safety monograph for INSPRA (INSPRA).	Aldosterone Receptor Antagonist	caution
IWILFIN Comprehensive clinical and safety monograph for IWILFIN (IWILFIN).	Mineralocorticoid Receptor Antagonist	caution
IZBA Comprehensive clinical and safety monograph for IZBA (IZBA).	Angiotensin II Receptor Antagonist	caution
JANTOVEN Comprehensive clinical and safety monograph for JANTOVEN (JANTOVEN).	Vitamin K Antagonist	caution
JYNARQUE Comprehensive clinical and safety monograph for JYNARQUE (JYNARQUE).	Vasopressin Receptor Antagonist	caution
KAPSPARGO SPRINKLE Comprehensive clinical and safety monograph for KAPSPARGO SPRINKLE (KAPSPARGO SPRINKLE).	Aldosterone Antagonist	caution
KERENDIA Comprehensive clinical and safety monograph for KERENDIA (KERENDIA).	Mineralocorticoid Receptor Antagonist	caution
KEVZARA Comprehensive clinical and safety monograph for KEVZARA (KEVZARA).	Monoclonal Antibody, IL-6 Receptor Antagonist	caution
KINERET Comprehensive clinical and safety monograph for KINERET (KINERET).	Interleukin-1 Receptor Antagonist	caution
KITPROZY Comprehensive clinical and safety monograph for KITPROZY (KITPROZY).	Interleukin-5 Antagonist Monoclonal Antibody	caution
KLOXXADO Comprehensive clinical and safety monograph for KLOXXADO (KLOXXADO).	Opioid Antagonist	caution
KORLYM Comprehensive clinical and safety monograph for KORLYM (KORLYM).	Glucocorticoid Receptor Antagonist	caution
KYRA Comprehensive clinical and safety monograph for KYRA (KYRA).	Estrogen Agonist/Antagonist	caution
KYTRIL Comprehensive clinical and safety monograph for KYTRIL (KYTRIL).	Antiemetic (5-HT3 Antagonist)	caution
LASMIDITAN Comprehensive clinical and safety monograph for LASMIDITAN (LASMIDITAN).	CGRP Receptor Antagonist	caution
LETAIRIS Comprehensive clinical and safety monograph for LETAIRIS (LETAIRIS).	Endothelin Receptor Antagonist	caution
LEUSTATIN Comprehensive clinical and safety monograph for LEUSTATIN (LEUSTATIN).	Antineoplastic (Purine Antagonist)	caution
LORFAN Comprehensive clinical and safety monograph for LORFAN (LORFAN).	Opioid antagonist	caution
LOTRONEX Comprehensive clinical and safety monograph for LOTRONEX (LOTRONEX).	5-HT3 Receptor Antagonist	caution
MACITENTAN Strong CYP3A4 inducers may decrease efficacy Contraindicated in pregnancy due to fetal toxicity.	Endothelin Receptor Antagonist	avoid
MARAVIROC Strong CYP3A4 inhibitors or inducers require dose adjustment Can cause hepatotoxicity and orthostatic hypotension.	CCR5 Antagonist	safe
MEMANTINE HYDROCHLORIDE Drugs that make urine alkaline (eg carbonic anhydrase inhibitors) may decrease excretion Generally well-tolerated with dizziness being the most common side effect.	NMDA Receptor Antagonist	safe
MEMANTINE HYDROCHLORIDE AND DONEPEZIL HYDROCHLORIDE Drugs that make urine alkaline (eg carbonic anhydrase inhibitors) may decrease excretion Generally well-tolerated with dizziness being the most common side effect.	NMDA Receptor Antagonist	safe
METHYLNALTREXONE BROMIDE No significant drug interactions Can precipitate acute withdrawal in patients dependent on opioids.	Peripheral Opioid Receptor Antagonist	safe
METOCLOPRAMIDE CNS depressants may enhance sedative effects Can cause extrapyramidal symptoms and tardive dyskinesia.	Dopamine Antagonist	safe
METOCLOPRAMIDE HCL CNS depressants may enhance sedative effects Can cause extrapyramidal symptoms and tardive dyskinesia.	Dopamine Antagonist	safe
METOCLOPRAMIDE HYDROCHLORIDE CNS depressants may enhance sedative effects Can cause extrapyramidal symptoms and tardive dyskinesia.	Dopamine Antagonist	safe
METOCLOPRAMIDE INTENSOL CNS depressants may enhance sedative effects Can cause extrapyramidal symptoms and tardive dyskinesia.	Dopamine Antagonist	safe
Montelukast Used for asthma and allergic rhinitis. Human pregnancy data are limited but reassuring — no consistent increase in malformations in available cohort studies. The FDA added a boxed warning in 2020 regarding neuropsychiatric events (not pregnancy-specific). Inhaled corticosteroids and beta-agonists remain first-line for asthma in pregnancy; montelukast may be continued if the patient was well-controlled on it prior to pregnancy.	Leukotriene Receptor Antagonist	caution
MONTELUKAST SODIUM Phenobarbital may decrease levels Can cause neuropsychiatric events including agitation and depression.	Leukotriene Receptor Antagonist	safe
MOVANTIK Comprehensive clinical and safety monograph for MOVANTIK (MOVANTIK).	Peripherally Acting Mu-Opioid Receptor Antagonist	caution
MYZILRA Comprehensive clinical and safety monograph for MYZILRA (MYZILRA).	CGRP Antagonist	caution
NALBUPHINE CNS depressants may enhance sedative effects Can cause withdrawal in patients dependent on other opioids.	Opioid Agonist-Antagonist	safe
NALBUPHINE HYDROCHLORIDE CNS depressants may enhance sedative effects Can cause withdrawal in patients dependent on other opioids.	Opioid Agonist-Antagonist	safe
NALMEFENE HYDROCHLORIDE Comprehensive clinical and safety monograph for NALMEFENE HYDROCHLORIDE (NALMEFENE HYDROCHLORIDE).	Opioid Antagonist	caution
NALOXEGOL Comprehensive clinical and safety monograph for NALOXEGOL (NALOXEGOL).	Opioid Antagonist	caution
NALOXONE No significant drug interactions Can precipitate acute withdrawal in patients dependent on opioids.	Opioid Antagonist	safe
NALOXONE HCL No significant drug interactions Can precipitate acute withdrawal in patients dependent on opioids.	Opioid Antagonist	safe
NALOXONE HYDROCHLORIDE No significant drug interactions Can precipitate acute withdrawal in patients dependent on opioids.	Opioid Antagonist	safe
NALOXONE HYDROCHLORIDE (AUTOINJECTOR) No significant drug interactions Can precipitate acute withdrawal in patients dependent on opioids.	Opioid Antagonist	safe
NALOXONE HYDROCHLORIDE AND PENTAZOCINE HYDROCHLORIDE CNS depressants may enhance sedative effects Can cause withdrawal in patients dependent on other opioids.	Opioid Agonist-Antagonist	safe
NALTREXONE No significant drug interactions Can precipitate acute withdrawal in patients dependent on opioids.	Opioid Antagonist	safe
NALTREXONE HYDROCHLORIDE No significant drug interactions Can precipitate acute withdrawal in patients dependent on opioids.	Opioid Antagonist	safe
NAMENDA Comprehensive clinical and safety monograph for NAMENDA (NAMENDA).	NMDA Antagonist	caution
NAMENDA XR Comprehensive clinical and safety monograph for NAMENDA XR (NAMENDA XR).	NMDA Antagonist	caution
NARCAN Comprehensive clinical and safety monograph for NARCAN (NARCAN).	Opioid Antagonist	caution
NEFAZODONE HYDROCHLORIDE MAOIs can cause serotonin syndrome and CYP3A4 inhibitors may increase levels Can cause rare but serious hepatotoxicity.	Serotonin Antagonist and Reuptake Inhibitor (SARI)	safe
NOURIANZ Comprehensive clinical and safety monograph for NOURIANZ (NOURIANZ).	Adenosine A2A Receptor Antagonist (Anti-Parkinson)	caution
NUCALA Comprehensive clinical and safety monograph for NUCALA (NUCALA).	Monoclonal Antibody (IL-5 Antagonist)	caution
NUEDEXTA Comprehensive clinical and safety monograph for NUEDEXTA (NUEDEXTA).	NMDA Receptor Antagonist	caution
NURTEC ODT Comprehensive clinical and safety monograph for NURTEC ODT (NURTEC ODT).	CGRP Antagonist	caution
OMVOH Comprehensive clinical and safety monograph for OMVOH (OMVOH).	Interleukin-23 Antagonist	caution
Ondansetron Effective for moderate-to-severe nausea and vomiting of pregnancy (NVP) and hyperemesis gravidarum (HG) refractory to first-line agents. Early reports of cleft palate risk (Danish cohort, Pasternak 2010) were not consistently replicated in subsequent larger studies including a 2014 Swedish cohort (>1.8 million pregnancies) which found no significant increase in major malformations. Current consensus supports use when first-line options fail, with shared decision-making in T1. Small signal of cardiac septal defects in some studies has not been confirmed.	5-HT3 Antagonist	caution
ONDANSETRON HYDROCHLORIDE Drugs that prolong the QT interval may have additive effects Can cause QT prolongation and subsequent arrhythmias.	5-HT3 Antagonist	safe
ONDANSETRON HYDROCHLORIDE AND DEXTROSE IN PLASTIC CONTAINER Drugs that prolong the QT interval may have additive effects Can cause QT prolongation and subsequent arrhythmias.	5-HT3 Antagonist	safe
ONDANSETRON HYDROCHLORIDE PRESERVATIVE FREE Drugs that prolong the QT interval may have additive effects Can cause QT prolongation and subsequent arrhythmias.	5-HT3 Antagonist	safe
ONSURA Comprehensive clinical and safety monograph for ONSURA (ONSURA).	Peripherally-Acting Mu-Opioid Receptor Antagonist (PAMORA)	caution
ONTRUZANT Comprehensive clinical and safety monograph for ONTRUZANT (ONTRUZANT).	HER2/neu Receptor Antagonist (Monoclonal Antibody)	caution
OPSUMIT Comprehensive clinical and safety monograph for OPSUMIT (OPSUMIT).	Endothelin Receptor Antagonist (PAH)	caution
OPSYNVI Comprehensive clinical and safety monograph for OPSYNVI (OPSYNVI).	Endothelin Receptor Antagonist/Phosphodiesterase-5 Inhibitor Combination (PAH)	caution
OPVEE Comprehensive clinical and safety monograph for OPVEE (OPVEE).	Opioid Antagonist	caution
ORALTAG Comprehensive clinical and safety monograph for ORALTAG (ORALTAG).	H2 Receptor Antagonist	caution
ORAVERSE Comprehensive clinical and safety monograph for ORAVERSE (ORAVERSE).	Benzodiazepine Antagonist	caution
ORGOVYX Comprehensive clinical and safety monograph for ORGOVYX (ORGOVYX).	GnRH receptor antagonist	caution
ORIAHNN (COPACKAGED) Comprehensive clinical and safety monograph for ORIAHNN (COPACKAGED) (ORIAHNN (COPACKAGED)).	GnRH receptor antagonist combination	caution
ORILISSA Comprehensive clinical and safety monograph for ORILISSA (ORILISSA).	GnRH receptor antagonist	caution
ORMALVI Comprehensive clinical and safety monograph for ORMALVI (ORMALVI).	Progesterone receptor antagonist	caution
ORSERDU Comprehensive clinical and safety monograph for ORSERDU (ORSERDU).	Estrogen receptor antagonist	caution
PALONOSETRON HYDROCHLORIDE No significant drug interactions Generally well-tolerated with constipation being the most common side effect.	5-HT3 Antagonist	safe
PEPCID Comprehensive clinical and safety monograph for PEPCID (PEPCID).	H2 Receptor Antagonist	caution
PEPCID AC Comprehensive clinical and safety monograph for PEPCID AC (PEPCID AC).	H2 Receptor Antagonist	caution
PEPCID COMPLETE Comprehensive clinical and safety monograph for PEPCID COMPLETE (PEPCID COMPLETE).	H2 Receptor Antagonist	caution
PEPCID PRESERVATIVE FREE Comprehensive clinical and safety monograph for PEPCID PRESERVATIVE FREE (PEPCID PRESERVATIVE FREE).	H2 Receptor Antagonist	caution
PEPCID PRESERVATIVE FREE IN PLASTIC CONTAINER Comprehensive clinical and safety monograph for PEPCID PRESERVATIVE FREE IN PLASTIC CONTAINER (PEPCID PRESERVATIVE FREE IN PLASTIC CONTAINER).	H2 Receptor Antagonist	caution
PEPCID RPD Comprehensive clinical and safety monograph for PEPCID RPD (PEPCID RPD).	H2 Receptor Antagonist	caution
PERAMPANEL Strong CYP3A4 inducers may decrease efficacy Can cause serious neuropsychiatric events including aggression and hostility.	AMPA Receptor Antagonist	safe
PERJETA Comprehensive clinical and safety monograph for PERJETA (PERJETA).	HER2 Antagonist	caution
PITOLISANT Comprehensive clinical and safety monograph for PITOLISANT (PITOLISANT).	Histamine H3 Receptor Antagonist	caution
PLENAXIS Comprehensive clinical and safety monograph for PLENAXIS (PLENAXIS).	Aldosterone Antagonist	caution
QBRELIS Comprehensive clinical and safety monograph for QBRELIS (QBRELIS).	Bradykinin B2 Receptor Antagonist	caution
QULIPTA Comprehensive clinical and safety monograph for QULIPTA (QULIPTA).	CGRP Antagonist	caution
QUVIVIQ Comprehensive clinical and safety monograph for QUVIVIQ (QUVIVIQ).	Dual Orexin Receptor Antagonist	caution
RANICLOR Comprehensive clinical and safety monograph for RANICLOR (RANICLOR).	H2 Receptor Antagonist	caution
RAPAFLO Comprehensive clinical and safety monograph for RAPAFLO (RAPAFLO).	Alpha-1 Adrenergic Antagonist	caution
REGITINE Comprehensive clinical and safety monograph for REGITINE (REGITINE).	Alpha-Adrenergic Antagonist	caution
REGLAN Comprehensive clinical and safety monograph for REGLAN (REGLAN).	Dopamine Antagonist Antiemetic	caution
REGLAN ODT Comprehensive clinical and safety monograph for REGLAN ODT (REGLAN ODT).	Dopamine Antagonist Antiemetic	caution
RELISTOR Comprehensive clinical and safety monograph for RELISTOR (RELISTOR).	Peripheral Opioid Antagonist	caution
REVEX Comprehensive clinical and safety monograph for REVEX (REVEX).	Opioid Antagonist	caution
REVIA Comprehensive clinical and safety monograph for REVIA (REVIA).	Opioid Antagonist	caution
RIMEGEPANT Comprehensive clinical and safety monograph for RIMEGEPANT (RIMEGEPANT).	CGRP Receptor Antagonist	caution
ROMAZICON Comprehensive clinical and safety monograph for ROMAZICON (ROMAZICON).	Benzodiazepine Antagonist	caution
SAMSCA Comprehensive clinical and safety monograph for SAMSCA (SAMSCA).	Vasopressin Receptor Antagonist	caution
SANCUSO Comprehensive clinical and safety monograph for SANCUSO (SANCUSO).	5-HT3 Receptor Antagonist	caution
SANSERT Comprehensive clinical and safety monograph for SANSERT (SANSERT).	Serotonin Antagonist	caution
SELZENTRY Comprehensive clinical and safety monograph for SELZENTRY (SELZENTRY).	CCR5 Antagonist	caution
SIMULECT Comprehensive clinical and safety monograph for SIMULECT (SIMULECT).	Interleukin-2 Receptor Antagonist	caution
SINGULAIR Comprehensive clinical and safety monograph for SINGULAIR (SINGULAIR).	Leukotriene receptor antagonist	caution
SOMAVERT Comprehensive clinical and safety monograph for SOMAVERT (SOMAVERT).	Growth Hormone Receptor Antagonist	caution
SPEVIGO Comprehensive clinical and safety monograph for SPEVIGO (SPEVIGO).	Biologic (IL-36 receptor antagonist)	caution
SPIRONOLACTONE ACE inhibitors and ARBs may increase risk of hyperkalemia Can cause hyperkalemia and gynecomastia.	Aldosterone Antagonist	avoid
SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE ACE inhibitors and ARBs may increase risk of hyperkalemia Can cause hyperkalemia and gynecomastia.	Aldosterone Antagonist	avoid
SPIRONOLACTONE W/ HYDROCHLOROTHIAZIDE ACE inhibitors and ARBs may increase risk of hyperkalemia Can cause hyperkalemia and gynecomastia.	Aldosterone Antagonist	avoid
SPRAVATO Comprehensive clinical and safety monograph for SPRAVATO (SPRAVATO).	NMDA Antagonist Antidepressant	caution
SUSTOL Comprehensive clinical and safety monograph for SUSTOL (SUSTOL).	Serotonin 5-HT3 Receptor Antagonist	caution
SUVOREXANT Comprehensive clinical and safety monograph for SUVOREXANT (SUVOREXANT).	Orexin Receptor Antagonist Hypnotic	caution
SYMPROIC Comprehensive clinical and safety monograph for SYMPROIC (SYMPROIC).	Opioid Antagonist (PAMORA)	caution
TAGAMET Comprehensive clinical and safety monograph for TAGAMET (TAGAMET).	H2 receptor antagonist	caution
TAGAMET HB Comprehensive clinical and safety monograph for TAGAMET HB (TAGAMET HB).	H2 receptor antagonist	caution
TAGAMET HB 200 Comprehensive clinical and safety monograph for TAGAMET HB 200 (TAGAMET HB 200).	H2 receptor antagonist	caution
TALWIN NX Comprehensive clinical and safety monograph for TALWIN NX (TALWIN NX).	Opioid Partial Agonist/Antagonist	caution
TAVNEOS Comprehensive clinical and safety monograph for TAVNEOS (TAVNEOS).	Complement C5a Receptor Antagonist	caution
TEPEZZA Comprehensive clinical and safety monograph for TEPEZZA (TEPEZZA).	IGF-1 receptor antagonist (monoclonal antibody)	caution
TOLVAPTAN Comprehensive clinical and safety monograph for TOLVAPTAN (TOLVAPTAN).	Vaptan (Vasopressin Receptor Antagonist)	caution
TRACLEER Comprehensive clinical and safety monograph for TRACLEER (TRACLEER).	Endothelin Receptor Antagonist	caution
TRAZODONE HYDROCHLORIDE CNS depressants may enhance sedative effects Can cause priapism a medical emergency.	Serotonin Antagonist and Reuptake Inhibitor (SARI)	safe
TRITEC Comprehensive clinical and safety monograph for TRITEC (TRITEC).	H2 Receptor Antagonist/Antimicrobial Combination	caution
TYENNE Comprehensive clinical and safety monograph for TYENNE (TYENNE).	Interleukin-6 receptor antagonist	caution
UBRELVY Comprehensive clinical and safety monograph for UBRELVY (UBRELVY).	CGRP Antagonist	caution
UBROGEPANT Comprehensive clinical and safety monograph for UBROGEPANT (UBROGEPANT).	CGRP Antagonist	caution
VAPRISOL Comprehensive clinical and safety monograph for VAPRISOL (VAPRISOL).	Vasopressin Receptor Antagonist	caution
VAPRISOL IN 5% DEXTROSE IN PLASTIC CONTAINER Comprehensive clinical and safety monograph for VAPRISOL IN 5% DEXTROSE IN PLASTIC CONTAINER (VAPRISOL IN 5% DEXTROSE IN PLASTIC CONTAINER).	Vasopressin Receptor Antagonist	caution
VARUBI Comprehensive clinical and safety monograph for VARUBI (VARUBI).	Antiemetic (NK1 Receptor Antagonist)	caution
VEOZAH Comprehensive clinical and safety monograph for VEOZAH (VEOZAH).	NK3 Receptor Antagonist	caution
VIVITROL Comprehensive clinical and safety monograph for VIVITROL (VIVITROL).	Opioid Antagonist	caution
VYEPTI Comprehensive clinical and safety monograph for VYEPTI (VYEPTI).	CGRP Antagonist (Migraine Prevention)	caution
VYVGART Comprehensive clinical and safety monograph for VYVGART (VYVGART).	FcRn Antagonist	caution
VYVGART HYTRULO Comprehensive clinical and safety monograph for VYVGART HYTRULO (VYVGART HYTRULO).	FcRn Antagonist	caution
WAKIX Comprehensive clinical and safety monograph for WAKIX (WAKIX).	Histamine H3 Antagonist (Narcolepsy)	caution
Warfarin Contraindicated in most circumstances. Warfarin is a proven human teratogen. Exposure between 6–9 weeks gestation causes Fetal Warfarin Syndrome: nasal hypoplasia, stippled epiphyses, and limb defects in approximately 5% of exposed fetuses. Any trimester exposure carries risk of fetal intracranial hemorrhage due to anticoagulation of the fetal blood. Exception: women with mechanical heart valves may require warfarin due to inadequate LMWH valve protection — this requires individualized multidisciplinary decision-making.	Anticoagulant (Vitamin K Antagonist)	avoid
WARFARIN SODIUM A vast number of drugs can increase or decrease INR through various mechanisms Has a narrow therapeutic index and requires frequent INR monitoring to prevent bleeding or clotting.	Anticoagulant (Vitamin K Antagonist)	avoid
YESINTEK Comprehensive clinical and safety monograph for YESINTEK (YESINTEK).	Interleukin Inhibitor (IL-12/23 antagonist)	caution
YUPELRI Comprehensive clinical and safety monograph for YUPELRI (YUPELRI).	Long-Acting Muscarinic Antagonist	caution
ZAFIRLUKAST Warfarin metabolism is inhibited increasing INR Can cause hepatic failure and Churg-Strauss syndrome.	Leukotriene Receptor Antagonist	safe
ZANTAC Comprehensive clinical and safety monograph for ZANTAC (ZANTAC).	H2 Receptor Antagonist	caution
ZANTAC 150 Comprehensive clinical and safety monograph for ZANTAC 150 (ZANTAC 150).	H2 Antagonist	caution
ZANTAC 25 Comprehensive clinical and safety monograph for ZANTAC 25 (ZANTAC 25).	H2 Antagonist	caution
ZANTAC 300 Comprehensive clinical and safety monograph for ZANTAC 300 (ZANTAC 300).	H2 Antagonist	caution
ZANTAC 75 Comprehensive clinical and safety monograph for ZANTAC 75 (ZANTAC 75).	H2 Antagonist	caution
ZANTAC IN PLASTIC CONTAINER Comprehensive clinical and safety monograph for ZANTAC IN PLASTIC CONTAINER (ZANTAC IN PLASTIC CONTAINER).	H2 Antagonist	caution
ZAVZPRET Comprehensive clinical and safety monograph for ZAVZPRET (ZAVZPRET).	CGRP Receptor Antagonist	caution
ZEGALOGUE Comprehensive clinical and safety monograph for ZEGALOGUE (ZEGALOGUE).	GnRH Antagonist	caution
ZEGALOGUE (AUTOINJECTOR) Comprehensive clinical and safety monograph for ZEGALOGUE (AUTOINJECTOR) (ZEGALOGUE (AUTOINJECTOR)).	GnRH Antagonist	caution
ZIMHI Comprehensive clinical and safety monograph for ZIMHI (ZIMHI).	Opioid Antagonist	caution
ZOFRAN Comprehensive clinical and safety monograph for ZOFRAN (ZOFRAN).	Antiemetic (5-HT3 Antagonist)	caution
ZOFRAN AND DEXTROSE IN PLASTIC CONTAINER Comprehensive clinical and safety monograph for ZOFRAN AND DEXTROSE IN PLASTIC CONTAINER (ZOFRAN AND DEXTROSE IN PLASTIC CONTAINER).	Antiemetic (5-HT3 Antagonist)	caution
ZOFRAN ODT Comprehensive clinical and safety monograph for ZOFRAN ODT (ZOFRAN ODT).	Antiemetic (5-HT3 Antagonist)	caution
ZOFRAN PRESERVATIVE FREE Comprehensive clinical and safety monograph for ZOFRAN PRESERVATIVE FREE (ZOFRAN PRESERVATIVE FREE).	Antiemetic (5-HT3 Antagonist)	caution

This therapeutic registry is dynamically synthesized from professional clinical sources. Listing of a medication does not imply equivalence; refer to individual monographs for head-to-head pharmacological data.