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Clinical Notice:OpiCalc is not a substitute for professional clinical judgment. Always verify dosages and guidelines.

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Registry Hub

Therapeutic Classification

anticonvulsant Registry

Clinical reference for anticonvulsant medications. Access safety monographs, dosing adjustments, and drug-drug interactions for all registered brand names and generics in this class.

Registered Medications (anticonvulsant)

This therapeutic registry is dynamically synthesized from professional clinical sources. Listing of a medication does not imply equivalence; refer to individual monographs for head-to-head pharmacological data.

MedicationTherapeutic ClassMaternal Safety

APTIOM

Comprehensive clinical and safety monograph for APTIOM (APTIOM).

Anticonvulsant

caution

ATZUMI

Comprehensive clinical and safety monograph for ATZUMI (ATZUMI).

Benzodiazepine Anticonvulsant

caution

AZMIRO

Comprehensive clinical and safety monograph for AZMIRO (AZMIRO).

Anticonvulsant

caution

BANZEL

Comprehensive clinical and safety monograph for BANZEL (BANZEL).

Anticonvulsant

caution

BIORPHEN

Comprehensive clinical and safety monograph for BIORPHEN (BIORPHEN).

Anticonvulsant

caution

BRIVARACETAM

Comprehensive clinical and safety monograph for BRIVARACETAM (BRIVARACETAM).

Anticonvulsant

caution

BRIVIACT

Comprehensive clinical and safety monograph for BRIVIACT (BRIVIACT).

Anticonvulsant

caution

CARBAMAZEPINE

Induces CYP450 enzymes reducing levels of many drugs (eg oral contraceptives warfarin) HLA-B*1502 allele increases risk of serious skin reactions in certain populations.

Anticonvulsant

avoid

CARBATROL

Comprehensive clinical and safety monograph for CARBATROL (CARBATROL).

Anticonvulsant

caution

CELONTIN

Comprehensive clinical and safety monograph for CELONTIN (CELONTIN).

Anticonvulsant

caution

CENOBAMATE

Comprehensive clinical and safety monograph for CENOBAMATE (CENOBAMATE).

Anticonvulsant

caution

CEREBYX

Comprehensive clinical and safety monograph for CEREBYX (CEREBYX).

Anticonvulsant

caution

DEPACON

Comprehensive clinical and safety monograph for DEPACON (DEPACON).

Anticonvulsant

caution

DEPAKENE

Comprehensive clinical and safety monograph for DEPAKENE (DEPAKENE).

Anticonvulsant

caution

DEPAKOTE

Comprehensive clinical and safety monograph for DEPAKOTE (DEPAKOTE).

Anticonvulsant

caution

DEPAKOTE CP

Comprehensive clinical and safety monograph for DEPAKOTE CP (DEPAKOTE CP).

Anticonvulsant

caution

DEPAKOTE ER

Comprehensive clinical and safety monograph for DEPAKOTE ER (DEPAKOTE ER).

Anticonvulsant

caution

DIACOMIT

Comprehensive clinical and safety monograph for DIACOMIT (DIACOMIT).

Anticonvulsant

caution

DIASTAT

Comprehensive clinical and safety monograph for DIASTAT (DIASTAT).

Benzodiazepine Anticonvulsant

caution

DIASTAT ACUDIAL

Comprehensive clinical and safety monograph for DIASTAT ACUDIAL (DIASTAT ACUDIAL).

Benzodiazepine Anticonvulsant

caution

DILANTIN

Comprehensive clinical and safety monograph for DILANTIN (DILANTIN).

Anticonvulsant

caution

DILANTIN-125

Comprehensive clinical and safety monograph for DILANTIN-125 (DILANTIN-125).

Anticonvulsant

caution

DILANTIN-30

Comprehensive clinical and safety monograph for DILANTIN-30 (DILANTIN-30).

Anticonvulsant

caution

DIVALPROEX SODIUM

CYP450 enzyme inducers may decrease levels Can cause severe hepatotoxicity and teratogenic effects including neural tube defects.

Anticonvulsant

avoid

EPIDIOLEX

Comprehensive clinical and safety monograph for EPIDIOLEX (EPIDIOLEX).

Anticonvulsant

caution

EPITOL

Comprehensive clinical and safety monograph for EPITOL (EPITOL).

Anticonvulsant

caution

EPRONTIA

Comprehensive clinical and safety monograph for EPRONTIA (EPRONTIA).

Anticonvulsant

caution

EQUETRO

Comprehensive clinical and safety monograph for EQUETRO (EQUETRO).

Anticonvulsant

caution

ESLICARBAZEPINE ACETATE

Comprehensive clinical and safety monograph for ESLICARBAZEPINE ACETATE (ESLICARBAZEPINE ACETATE).

Anticonvulsant

caution

ETHOSUXIMIDE

CNS depressants may enhance sedative effects Can cause blood dyscrasias including aplastic anemia and SLE.

Anticonvulsant

caution

EXTENDED PHENYTOIN SODIUM

Many drugs can increase or decrease phenytoin levels Can cause life-threatening dermatologic reactions like Stevens-Johnson syndrome.

Anticonvulsant

avoid

FELBAMATE

Increases levels of phenytoin and valproic acid and decreases levels of carbamazepine Can cause aplastic anemia and hepatic failure.

Anticonvulsant

caution

FELBATOL

Comprehensive clinical and safety monograph for FELBATOL (FELBATOL).

Anticonvulsant

caution

FOSPHENYTOIN SODIUM

Many drugs can increase or decrease phenytoin levels Can cause life-threatening dermatologic reactions like Stevens-Johnson syndrome.

Anticonvulsant

avoid

FYCOMPA

Comprehensive clinical and safety monograph for FYCOMPA (FYCOMPA).

Anticonvulsant

caution

GABAPENTIN

Antacids decrease absorption May cause somnolence dizziness and respiratory depression especially with opioids.

Anticonvulsant

safe

GABAPENTIN ENACARBIL

Antacids decrease absorption May cause somnolence dizziness and respiratory depression especially with opioids.

Anticonvulsant

safe

GABAPENTIN ENCARBIL

Antacids decrease absorption May cause somnolence dizziness and respiratory depression especially with opioids.

Anticonvulsant

safe

GABITRIL

Comprehensive clinical and safety monograph for GABITRIL (GABITRIL).

Anticonvulsant

caution

GEMONIL

Comprehensive clinical and safety monograph for GEMONIL (GEMONIL).

Succinimide Anticonvulsant

caution

GRALISE

Comprehensive clinical and safety monograph for GRALISE (GRALISE).

Gabapentinoid Anticonvulsant

caution

HORIZANT

Comprehensive clinical and safety monograph for HORIZANT (HORIZANT).

Anticonvulsant (Gabapentinoid)

caution

KONVOMEP

Comprehensive clinical and safety monograph for KONVOMEP (KONVOMEP).

Anticonvulsant

caution

LACOSAMIDE

No significant drug interactions May cause dizziness and PR interval prolongation.

Anticonvulsant

caution

LAMICTAL

Comprehensive clinical and safety monograph for LAMICTAL (LAMICTAL).

Anticonvulsant

caution

LAMICTAL CD

Comprehensive clinical and safety monograph for LAMICTAL CD (LAMICTAL CD).

Anticonvulsant

caution

LAMICTAL ODT

Comprehensive clinical and safety monograph for LAMICTAL ODT (LAMICTAL ODT).

Anticonvulsant

caution

LAMICTAL XR

Comprehensive clinical and safety monograph for LAMICTAL XR (LAMICTAL XR).

Anticonvulsant

caution

Lamotrigine

The preferred antiepileptic drug for women of reproductive age and the most commonly used AED in pregnancy. Associated with the lowest major congenital malformation (MCM) rate of the major AEDs in the largest pregnancy registries (NAAED: approximately 2.0–2.4% vs. 2–3% background rate for low doses). Dose-dependent teratogenicity seen only at high doses (>300 mg/day) in some registries, but risk at therapeutic doses is low. Critical caveat: pregnancy significantly increases lamotrigine clearance (by up to 2–3×), requiring dose adjustment to prevent breakthrough seizures.

Anticonvulsant

safe

LEVETIRACETAM

No significant drug interactions May cause behavioral abnormalities including psychosis and aggression.

Anticonvulsant

safe

LYRICA

Comprehensive clinical and safety monograph for LYRICA (LYRICA).

Anticonvulsant

caution

LYRICA CR

Comprehensive clinical and safety monograph for LYRICA CR (LYRICA CR).

Anticonvulsant

caution

MESANTOIN

Comprehensive clinical and safety monograph for MESANTOIN (MESANTOIN).

Anticonvulsant (Hydantoin)

caution

METHSUXIMIDE

Comprehensive clinical and safety monograph for METHSUXIMIDE (METHSUXIMIDE).

Succinimide Anticonvulsant

caution

MYSOLINE

Comprehensive clinical and safety monograph for MYSOLINE (MYSOLINE).

Anticonvulsant

caution

ONFI

Comprehensive clinical and safety monograph for ONFI (ONFI).

Benzodiazepine Anticonvulsant

caution

OXCARBAZEPINE

Strong CYP3A4 inducers may decrease levels of active metabolite Can cause hyponatremia and cross-hypersensitivity with carbamazepine.

Anticonvulsant

caution

OXCARBAZEPINE EXTENDED RELEASE TABLETS

Strong CYP3A4 inducers may decrease levels of active metabolite Can cause hyponatremia and cross-hypersensitivity with carbamazepine.

Anticonvulsant

caution

PARADIONE

Comprehensive clinical and safety monograph for PARADIONE (PARADIONE).

Anticonvulsant

caution

PEGANONE

Comprehensive clinical and safety monograph for PEGANONE (PEGANONE).

Anticonvulsant (Hydantoin)

caution

PHENTERMINE HYDROCHLORIDE AND TOPIRAMATE

Can decrease efficacy of oral contraceptives and other drugs by inducing CYP450 enzymes Can cause metabolic acidosis and angle-closure glaucoma.

Anticonvulsant

caution

PHENURONE

Comprehensive clinical and safety monograph for PHENURONE (PHENURONE).

Anticonvulsant

caution

PHENYTEK

Comprehensive clinical and safety monograph for PHENYTEK (PHENYTEK).

Anticonvulsant

caution

PHENYTEX

Comprehensive clinical and safety monograph for PHENYTEX (PHENYTEX).

Anticonvulsant

caution

PHENYTOIN

Many drugs can increase or decrease phenytoin levels Can cause life-threatening dermatologic reactions like Stevens-Johnson syndrome.

Anticonvulsant

avoid

PHENYTOIN SODIUM

Many drugs can increase or decrease phenytoin levels Can cause life-threatening dermatologic reactions like Stevens-Johnson syndrome.

Anticonvulsant

avoid

PREGABALIN

CNS depressants may enhance sedative effects Can cause angioedema and withdrawal symptoms upon discontinuation.

Anticonvulsant

safe

PRIMIDONE

CNS depressants may enhance sedative effects Can cause sedation and megaloblastic anemia.

Anticonvulsant

avoid

PROMPT PHENYTOIN SODIUM

Many drugs can increase or decrease phenytoin levels Can cause life-threatening dermatologic reactions like Stevens-Johnson syndrome.

Anticonvulsant

avoid

QUDEXY XR

Comprehensive clinical and safety monograph for QUDEXY XR (QUDEXY XR).

Anticonvulsant

caution

RELGAABI

Comprehensive clinical and safety monograph for RELGAABI (RELGAABI).

Gabapentinoid Anticonvulsant

caution

SABRIL

Comprehensive clinical and safety monograph for SABRIL (SABRIL).

GABA Transaminase Inhibitor Anticonvulsant

caution

SEIZALAM

Comprehensive clinical and safety monograph for SEIZALAM (SEIZALAM).

Benzodiazepine Anticonvulsant

caution

SITAVIG

Comprehensive clinical and safety monograph for SITAVIG (SITAVIG).

Anticonvulsant

caution

SYMPAZAN

Comprehensive clinical and safety monograph for SYMPAZAN (SYMPAZAN).

Benzodiazepine Anticonvulsant

caution

TEGRETOL

Comprehensive clinical and safety monograph for TEGRETOL (TEGRETOL).

Anticonvulsant

caution

TEGRETOL-XR

Comprehensive clinical and safety monograph for TEGRETOL-XR (TEGRETOL-XR).

Anticonvulsant

caution

TIAGABINE HYDROCHLORIDE

Strong CYP3A4 inducers may decrease efficacy Can cause seizures in patients without epilepsy.

Anticonvulsant

safe

TOPAMAX

Comprehensive clinical and safety monograph for TOPAMAX (TOPAMAX).

Anticonvulsant

caution

TOPAMAX SPRINKLE

Comprehensive clinical and safety monograph for TOPAMAX SPRINKLE (TOPAMAX SPRINKLE).

Anticonvulsant

caution

TRIDIONE

Comprehensive clinical and safety monograph for TRIDIONE (TRIDIONE).

Anticonvulsant

caution

TRILEPTAL

Comprehensive clinical and safety monograph for TRILEPTAL (TRILEPTAL).

Anticonvulsant

caution

TROKENDI XR

Comprehensive clinical and safety monograph for TROKENDI XR (TROKENDI XR).

Anticonvulsant (Sulfamate-substituted monosaccharide)

caution

VALPROATE SODIUM

Comprehensive clinical and safety monograph for VALPROATE SODIUM (VALPROATE SODIUM).

Anticonvulsant

caution

VALPROIC ACID

CYP450 enzyme inducers may decrease levels Can cause severe hepatotoxicity and teratogenic effects including neural tube defects.

Anticonvulsant

avoid

VALRELEASE

Comprehensive clinical and safety monograph for VALRELEASE (VALRELEASE).

Anticonvulsant

caution

VALTOCO

Comprehensive clinical and safety monograph for VALTOCO (VALTOCO).

Benzodiazepine Anticonvulsant

caution

VIGABATRIN

Other drugs that cause visual field defects may have additive effects Can cause permanent concentric visual field constriction.

Anticonvulsant

safe

VIGADRONE

Comprehensive clinical and safety monograph for VIGADRONE (VIGADRONE).

Anticonvulsant

caution

VIGAFYDE

Comprehensive clinical and safety monograph for VIGAFYDE (VIGAFYDE).

Anticonvulsant

caution

VIGPODER

Comprehensive clinical and safety monograph for VIGPODER (VIGPODER).

Anticonvulsant

caution

VIMPAT

Comprehensive clinical and safety monograph for VIMPAT (VIMPAT).

Anticonvulsant

caution

XCOPRI

Comprehensive clinical and safety monograph for XCOPRI (XCOPRI).

Anticonvulsant

caution

ZARONTIN

Comprehensive clinical and safety monograph for ZARONTIN (ZARONTIN).

Anticonvulsant

caution

ZONEGRAN

Comprehensive clinical and safety monograph for ZONEGRAN (ZONEGRAN).

Anticonvulsant

caution

ZONISADE

Comprehensive clinical and safety monograph for ZONISADE (ZONISADE).

Anticonvulsant

caution

ZONISAMIDE

Strong CYP3A4 inducers may decrease levels Can cause oligohydrosis and hyperthermia in children and metabolic acidosis.

Anticonvulsant

caution

ZTALMY

Comprehensive clinical and safety monograph for ZTALMY (ZTALMY).

Anticonvulsant

caution