Therapeutic Classification

antidepressant Registry

Clinical reference for antidepressant medications. Access safety monographs, dosing adjustments, and drug-drug interactions for all registered brand names and generics in this class.

Registered Medications (antidepressant)

Medication	Therapeutic Class	Maternal Safety
AMITID Comprehensive clinical and safety monograph for AMITID (AMITID).	Tricyclic Antidepressant	caution
AMITRIL Comprehensive clinical and safety monograph for AMITRIL (AMITRIL).	Tricyclic Antidepressant	caution
AMITRIPTYLINE HYDROCHLORIDE MAOIs can cause serotonin syndrome and hyperpyrexia Strong anticholinergic effects may occur with other drugs like benztropine Increased risk of suicide in children and young adults.	Tricyclic Antidepressant	caution
AMOXAPINE Comprehensive clinical and safety monograph for AMOXAPINE (AMOXAPINE).	Tricyclic Antidepressant	caution
ANAFRANIL Comprehensive clinical and safety monograph for ANAFRANIL (ANAFRANIL).	Tricyclic Antidepressant	caution
APLENZIN Comprehensive clinical and safety monograph for APLENZIN (APLENZIN).	Antidepressant	caution
ASENDIN Comprehensive clinical and safety monograph for ASENDIN (ASENDIN).	Tricyclic Antidepressant	caution
AUVELITY Comprehensive clinical and safety monograph for AUVELITY (AUVELITY).	Antidepressant	caution
AVENTYL Comprehensive clinical and safety monograph for AVENTYL (AVENTYL).	Tricyclic Antidepressant	caution
AVENTYL HYDROCHLORIDE Comprehensive clinical and safety monograph for AVENTYL HYDROCHLORIDE (AVENTYL HYDROCHLORIDE).	Tricyclic Antidepressant	caution
BRISDELLE Comprehensive clinical and safety monograph for BRISDELLE (BRISDELLE).	SSRI Antidepressant	caution
BUPROPION HYDROBROMIDE MAOIs can increase risk of hypertensive episodes Lowers seizure threshold in a dose-dependent manner.	Atypical Antidepressant	safe
BUPROPION HYDROCHLORIDE MAOIs can increase risk of hypertensive episodes Lowers seizure threshold in a dose-dependent manner.	Atypical Antidepressant	safe
CELEXA Comprehensive clinical and safety monograph for CELEXA (CELEXA).	SSRI Antidepressant	caution
CLOMIPRAMINE HYDROCHLORIDE MAOIs can cause serotonin syndrome and hyperpyrexia Strong anticholinergic effects may occur with other drugs Increased risk of suicide in children and young adults.	Tricyclic Antidepressant	caution
CYMBALTA Comprehensive clinical and safety monograph for CYMBALTA (CYMBALTA).	SNRI Antidepressant	caution
DESIPRAMINE HYDROCHLORIDE MAOIs can cause serotonin syndrome and hyperpyrexia Strong anticholinergic effects may occur with other drugs Increased risk of suicide in children and young adults.	Tricyclic Antidepressant	caution
DESYREL Comprehensive clinical and safety monograph for DESYREL (DESYREL).	Atypical Antidepressant	caution
DOXEPIN HYDROCHLORIDE MAOIs can cause serotonin syndrome and hyperpyrexia Strong anticholinergic effects may occur with other drugs Increased risk of suicide in children and young adults.	Tricyclic Antidepressant	caution
DRIZALMA SPRINKLE Comprehensive clinical and safety monograph for DRIZALMA SPRINKLE (DRIZALMA SPRINKLE).	SNRI Antidepressant	caution
EFFEXOR Comprehensive clinical and safety monograph for EFFEXOR (EFFEXOR).	SNRI Antidepressant	caution
EFFEXOR XR Comprehensive clinical and safety monograph for EFFEXOR XR (EFFEXOR XR).	SNRI Antidepressant	caution
ELAVIL Comprehensive clinical and safety monograph for ELAVIL (ELAVIL).	Tricyclic Antidepressant	caution
EMSAM Comprehensive clinical and safety monograph for EMSAM (EMSAM).	Monoamine Oxidase Inhibitor Antidepressant	caution
ENDEP Comprehensive clinical and safety monograph for ENDEP (ENDEP).	Tricyclic Antidepressant	caution
ETRAFON 2-10 Comprehensive clinical and safety monograph for ETRAFON 2-10 (ETRAFON 2-10).	Antipsychotic/Antidepressant Combination	caution
ETRAFON 2-25 Comprehensive clinical and safety monograph for ETRAFON 2-25 (ETRAFON 2-25).	Antipsychotic/Antidepressant Combination	caution
ETRAFON-A Comprehensive clinical and safety monograph for ETRAFON-A (ETRAFON-A).	Antipsychotic/Antidepressant Combination	caution
ETRAFON-FORTE Comprehensive clinical and safety monograph for ETRAFON-FORTE (ETRAFON-FORTE).	Antipsychotic/Antidepressant Combination	caution
EUTONYL Comprehensive clinical and safety monograph for EUTONYL (EUTONYL).	MAO Inhibitor Antidepressant	caution
FETZIMA Comprehensive clinical and safety monograph for FETZIMA (FETZIMA).	SNRI Antidepressant	caution
Fluoxetine-Safety-Postpartum For completeness: fluoxetine is also used postpartum for postnatal depression. The main breastfeeding consideration is its long half-life (fluoxetine + norfluoxetine) leading to measurable infant serum concentrations. While not contraindicated, sertraline or paroxetine are preferred for breastfeeding mothers. Separate slug to capture postnatal searches.	SSRI Antidepressant	safe
IMIPRAMINE HYDROCHLORIDE MAOIs can cause serotonin syndrome and hyperpyrexia Strong anticholinergic effects may occur with other drugs Increased risk of suicide in children and young adults.	Tricyclic Antidepressant	caution
IMIPRAMINE PAMOATE MAOIs can cause serotonin syndrome and hyperpyrexia Strong anticholinergic effects may occur with other drugs Increased risk of suicide in children and young adults.	Tricyclic Antidepressant	caution
JANIMINE Comprehensive clinical and safety monograph for JANIMINE (JANIMINE).	Tricyclic Antidepressant	caution
JOURNAVX Comprehensive clinical and safety monograph for JOURNAVX (JOURNAVX).	Neuroactive Steroid Antidepressant	caution
KALEXATE Comprehensive clinical and safety monograph for KALEXATE (KALEXATE).	SSRI Antidepressant	caution
KHEDEZLA Comprehensive clinical and safety monograph for KHEDEZLA (KHEDEZLA).	SNRI Antidepressant	caution
LEXAPRO Comprehensive clinical and safety monograph for LEXAPRO (LEXAPRO).	SSRI Antidepressant	caution
LIMBITROL Comprehensive clinical and safety monograph for LIMBITROL (LIMBITROL).	Benzodiazepine/Tricyclic Antidepressant Combination	caution
LIMBITROL DS Comprehensive clinical and safety monograph for LIMBITROL DS (LIMBITROL DS).	Benzodiazepine/Tricyclic Antidepressant Combination	caution
LUDIOMIL Comprehensive clinical and safety monograph for LUDIOMIL (LUDIOMIL).	Tetracyclic Antidepressant	caution
LUVOX Comprehensive clinical and safety monograph for LUVOX (LUVOX).	SSRI Antidepressant	caution
LUVOX CR Comprehensive clinical and safety monograph for LUVOX CR (LUVOX CR).	SSRI Antidepressant	caution
MAPROTILINE HYDROCHLORIDE MAOIs can cause serotonin syndrome and hyperpyrexia Can lower seizure threshold.	Tetracyclic Antidepressant	caution
MARPLAN Comprehensive clinical and safety monograph for MARPLAN (MARPLAN).	MAOI Antidepressant	caution
MILNACIPRAN HYDROCHLORIDE Comprehensive clinical and safety monograph for MILNACIPRAN HYDROCHLORIDE (MILNACIPRAN HYDROCHLORIDE).	SNRI Antidepressant	caution
MIRTAZAPINE CNS depressants may enhance sedative effects Can cause significant weight gain and somnolence.	Tetracyclic Antidepressant	safe
NARDIL Comprehensive clinical and safety monograph for NARDIL (NARDIL).	MAOI Antidepressant	caution
NORPRAMIN Comprehensive clinical and safety monograph for NORPRAMIN (NORPRAMIN).	Tricyclic Antidepressant	caution
NORTRIPTYLINE HYDROCHLORIDE MAOIs can cause serotonin syndrome and hyperpyrexia Strong anticholinergic effects may occur with other drugs Increased risk of suicide in children and young adults.	Tricyclic Antidepressant	caution
PAMELOR Comprehensive clinical and safety monograph for PAMELOR (PAMELOR).	Tricyclic Antidepressant	caution
PARNATE Comprehensive clinical and safety monograph for PARNATE (PARNATE).	MAOI Antidepressant	caution
PAXIL Comprehensive clinical and safety monograph for PAXIL (PAXIL).	SSRI Antidepressant	caution
PAXIL CR Comprehensive clinical and safety monograph for PAXIL CR (PAXIL CR).	SSRI Antidepressant	caution
PERTOFRANE Comprehensive clinical and safety monograph for PERTOFRANE (PERTOFRANE).	Tricyclic Antidepressant	caution
PEXEVA Comprehensive clinical and safety monograph for PEXEVA (PEXEVA).	SSRI Antidepressant	caution
PRAMINE Comprehensive clinical and safety monograph for PRAMINE (PRAMINE).	Tricyclic Antidepressant	caution
PRESAMINE Comprehensive clinical and safety monograph for PRESAMINE (PRESAMINE).	Tricyclic Antidepressant	caution
PRISTIQ Comprehensive clinical and safety monograph for PRISTIQ (PRISTIQ).	SNRI Antidepressant	caution
PROTRIPTYLINE HYDROCHLORIDE Comprehensive clinical and safety monograph for PROTRIPTYLINE HYDROCHLORIDE (PROTRIPTYLINE HYDROCHLORIDE).	Tricyclic Antidepressant	caution
PROZAC Comprehensive clinical and safety monograph for PROZAC (PROZAC).	SSRI Antidepressant	caution
PROZAC WEEKLY Comprehensive clinical and safety monograph for PROZAC WEEKLY (PROZAC WEEKLY).	SSRI Antidepressant	caution
QMIIZ ODT Comprehensive clinical and safety monograph for QMIIZ ODT (QMIIZ ODT).	Antidepressant	caution
REMERON Comprehensive clinical and safety monograph for REMERON (REMERON).	Noradrenergic and Specific Serotonergic Antidepressant (NaSSA)	caution
REMERON SOLTAB Comprehensive clinical and safety monograph for REMERON SOLTAB (REMERON SOLTAB).	Noradrenergic and Specific Serotonergic Antidepressant (NaSSA)	caution
SARAFEM Comprehensive clinical and safety monograph for SARAFEM (SARAFEM).	SSRI Antidepressant	caution
SAVELLA Comprehensive clinical and safety monograph for SAVELLA (SAVELLA).	SNRI Antidepressant	caution
SERZONE Comprehensive clinical and safety monograph for SERZONE (SERZONE).	Antidepressant	caution
SILENOR Comprehensive clinical and safety monograph for SILENOR (SILENOR).	Tricyclic Antidepressant	caution
SINEQUAN Comprehensive clinical and safety monograph for SINEQUAN (SINEQUAN).	Tricyclic antidepressant	caution
SPRAVATO Comprehensive clinical and safety monograph for SPRAVATO (SPRAVATO).	NMDA Antagonist Antidepressant	caution
SURMONTIL Comprehensive clinical and safety monograph for SURMONTIL (SURMONTIL).	Tricyclic Antidepressant	caution
SYMBYAX Comprehensive clinical and safety monograph for SYMBYAX (SYMBYAX).	Antidepressant/Antipsychotic Combination	caution
TIAMATE Comprehensive clinical and safety monograph for TIAMATE (TIAMATE).	Antidepressant	caution
TOFRANIL Comprehensive clinical and safety monograph for TOFRANIL (TOFRANIL).	Tricyclic antidepressant	caution
TOFRANIL-PM Comprehensive clinical and safety monograph for TOFRANIL-PM (TOFRANIL-PM).	Tricyclic antidepressant	caution
TRANYLCYPROMINE SULFATE Comprehensive clinical and safety monograph for TRANYLCYPROMINE SULFATE (TRANYLCYPROMINE SULFATE).	MAOI Antidepressant	caution
TRIAVIL 2-10 Comprehensive clinical and safety monograph for TRIAVIL 2-10 (TRIAVIL 2-10).	Antidepressant-Antipsychotic Combination	caution
TRIAVIL 2-25 Comprehensive clinical and safety monograph for TRIAVIL 2-25 (TRIAVIL 2-25).	Antidepressant-Antipsychotic Combination	caution
TRIAVIL 4-10 Comprehensive clinical and safety monograph for TRIAVIL 4-10 (TRIAVIL 4-10).	Antidepressant-Antipsychotic Combination	caution
TRIAVIL 4-25 Comprehensive clinical and safety monograph for TRIAVIL 4-25 (TRIAVIL 4-25).	Antidepressant-Antipsychotic Combination	caution
TRIAVIL 4-50 Comprehensive clinical and safety monograph for TRIAVIL 4-50 (TRIAVIL 4-50).	Antidepressant-Antipsychotic Combination	caution
TRIMIPRAMINE MALEATE MAOIs can cause serotonin syndrome and hyperpyrexia Strong anticholinergic effects may occur with other drugs Increased risk of suicide in children and young adults.	Tricyclic Antidepressant	caution
TRINTELLIX Comprehensive clinical and safety monograph for TRINTELLIX (TRINTELLIX).	Antidepressant	caution
VANTRELA ER Comprehensive clinical and safety monograph for VANTRELA ER (VANTRELA ER).	NDRI Antidepressant	caution
VIVACTIL Comprehensive clinical and safety monograph for VIVACTIL (VIVACTIL).	Tricyclic Antidepressant	caution
VORTIOXETINE MAOIs can cause serotonin syndrome Can cause nausea and increased risk of bleeding.	Multimodal Antidepressant	safe
VORTIOXETINE HYDROBROMIDE MAOIs can cause serotonin syndrome Can cause nausea and increased risk of bleeding.	Multimodal Antidepressant	safe
WELLBUTRIN Comprehensive clinical and safety monograph for WELLBUTRIN (WELLBUTRIN).	NDRI Antidepressant	caution
WELLBUTRIN SR Comprehensive clinical and safety monograph for WELLBUTRIN SR (WELLBUTRIN SR).	NDRI Antidepressant	caution
WELLBUTRIN XL Comprehensive clinical and safety monograph for WELLBUTRIN XL (WELLBUTRIN XL).	NDRI Antidepressant	caution
ZOLOFT Comprehensive clinical and safety monograph for ZOLOFT (ZOLOFT).	SSRI Antidepressant	caution
ZONALON Comprehensive clinical and safety monograph for ZONALON (ZONALON).	Topical Antipruritic (Tricyclic Antidepressant)	caution
ZULRESSO Comprehensive clinical and safety monograph for ZULRESSO (ZULRESSO).	Antidepressant	caution
ZURZUVAE Comprehensive clinical and safety monograph for ZURZUVAE (ZURZUVAE).	Neuroactive Steroid Antidepressant	caution
ZYBAN Comprehensive clinical and safety monograph for ZYBAN (ZYBAN).	Antidepressant, Smoking Cessation Aid	caution

This therapeutic registry is dynamically synthesized from professional clinical sources. Listing of a medication does not imply equivalence; refer to individual monographs for head-to-head pharmacological data.