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Registry Hub

Therapeutic Classification

azole antifungal Registry

Clinical reference for azole antifungal medications. Access safety monographs, dosing adjustments, and drug-drug interactions for all registered brand names and generics in this class.

Registered Medications (azole antifungal)

This therapeutic registry is dynamically synthesized from professional clinical sources. Listing of a medication does not imply equivalence; refer to individual monographs for head-to-head pharmacological data.

MedicationTherapeutic ClassMaternal Safety

ERMEZA

Comprehensive clinical and safety monograph for ERMEZA (ERMEZA).

Topical Azole Antifungal

caution

ERTACZO

Comprehensive clinical and safety monograph for ERTACZO (ERTACZO).

Topical Azole Antifungal

caution

Fluconazole

Oral fluconazole has a significant gestational-age-dependent risk profile. A single low dose (150 mg) for vaginal candidiasis is commonly used but increasingly scrutinized: a large 2016 Danish cohort (n=3,315) found a doubling of spontaneous abortion risk, and a 2020 NEJM study identified a significant association between single-dose and high-dose fluconazole use in T1 and cardiac septal defects. High-dose prolonged fluconazole (400–800 mg/day) is a known teratogen causing a distinctive skeletal malformation syndrome. Use topical azoles (clotrimazole, miconazole) as first-line for vaginal candidiasis.

Azole Antifungal

caution

FLUCONAZOLE IN DEXTROSE 5% IN PLASTIC CONTAINER

Inhibits CYP2C9 and CYP3A4 increasing levels of many drugs (eg warfarin phenytoin) Can cause QT prolongation and subsequent arrhythmias.

Azole Antifungal

safe

GYNAZOLE-1

Comprehensive clinical and safety monograph for GYNAZOLE-1 (GYNAZOLE-1).

Azole Antifungal

caution

GYNE-LOTRIMIN

Comprehensive clinical and safety monograph for GYNE-LOTRIMIN (GYNE-LOTRIMIN).

Azole Antifungal

caution

GYNE-LOTRIMIN 3

Comprehensive clinical and safety monograph for GYNE-LOTRIMIN 3 (GYNE-LOTRIMIN 3).

Azole Antifungal

caution

GYNE-LOTRIMIN 3 COMBINATION PACK

Comprehensive clinical and safety monograph for GYNE-LOTRIMIN 3 COMBINATION PACK (GYNE-LOTRIMIN 3 COMBINATION PACK).

Azole Antifungal

caution

GYNE-LOTRIMIN COMBINATION PACK

Comprehensive clinical and safety monograph for GYNE-LOTRIMIN COMBINATION PACK (GYNE-LOTRIMIN COMBINATION PACK).

Azole Antifungal

caution

ITRACONAZOLE

Inhibits CYP3A4 increasing levels of many drugs (eg statins) Contraindicated with drugs that prolong QT interval and can cause negative inotropy and heart failure.

Azole Antifungal

avoid

KETOCONAZOLE

Strong CYP3A4 inhibitor that can significantly increase levels of many drugs (eg statins) Contraindicated due to risk of hepatotoxicity and adrenal insufficiency.

Azole Antifungal

caution

MYCELEX

Comprehensive clinical and safety monograph for MYCELEX (MYCELEX).

Azole Antifungal

caution

MYCELEX-7

Comprehensive clinical and safety monograph for MYCELEX-7 (MYCELEX-7).

Azole Antifungal

caution

NIZORAL

Comprehensive clinical and safety monograph for NIZORAL (NIZORAL).

Azole Antifungal

caution

POSACONAZOLE

Comprehensive clinical and safety monograph for POSACONAZOLE (POSACONAZOLE).

Azole Antifungal

caution

POSFREA

Comprehensive clinical and safety monograph for POSFREA (POSFREA).

Azole Antifungal

caution

TERAZOL 3

Comprehensive clinical and safety monograph for TERAZOL 3 (TERAZOL 3).

Azole Antifungal

caution

TERAZOL 7

Comprehensive clinical and safety monograph for TERAZOL 7 (TERAZOL 7).

Azole Antifungal

caution

VAGISTAT-1

Comprehensive clinical and safety monograph for VAGISTAT-1 (VAGISTAT-1).

Azole Antifungal

caution

VORICONAZOLE

Inhibits CYP3A4 increasing levels of many drugs (eg statins) Can cause visual disturbances hepatotoxicity and photosensitivity.

Azole Antifungal

avoid