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Registry Hub

Therapeutic Classification

benzodiazepine Registry

Clinical reference for benzodiazepine medications. Access safety monographs, dosing adjustments, and drug-drug interactions for all registered brand names and generics in this class.

Registered Medications (benzodiazepine)

This therapeutic registry is dynamically synthesized from professional clinical sources. Listing of a medication does not imply equivalence; refer to individual monographs for head-to-head pharmacological data.

MedicationTherapeutic ClassMaternal Safety

A-POXIDE

Pregnancy category B (FDA). No adequate well-controlled studies in pregnant women; use only if clearly needed and benefit outweighs risk. Avoid use during the first trimester.

Benzodiazepine

caution

ALPRAZOLAM

Strong CYP3A4 inhibitors like ketoconazole can significantly increase levels Risk of profound sedation respiratory depression and coma if used with opioids or alcohol Abrupt discontinuation can cause seizures.

Benzodiazepine

avoid

ATIVAN

Comprehensive clinical and safety monograph for ATIVAN (ATIVAN).

Benzodiazepine

caution

ATZUMI

Comprehensive clinical and safety monograph for ATZUMI (ATZUMI).

Benzodiazepine Anticonvulsant

caution

BYFAVO

Comprehensive clinical and safety monograph for BYFAVO (BYFAVO).

Benzodiazepine

caution

CENTRAX

Comprehensive clinical and safety monograph for CENTRAX (CENTRAX).

Benzodiazepine

caution

CHLORDIAZACHEL

Comprehensive clinical and safety monograph for CHLORDIAZACHEL (CHLORDIAZACHEL).

Benzodiazepine

caution

CHLORDIAZEPOXIDE AND AMITRIPTYLINE HYDROCHLORIDE

CNS depressants including alcohol and opioids increase sedation risk Abrupt discontinuation can cause withdrawal symptoms.

Benzodiazepine

avoid

CHLORDIAZEPOXIDE HYDROCHLORIDE

CNS depressants including alcohol and opioids increase sedation risk Abrupt discontinuation can cause withdrawal symptoms.

Benzodiazepine

avoid

CHLORDIAZEPOXIDE HYDROCHLORIDE AND CLIDINIUM BROMIDE

CNS depressants including alcohol and opioids increase sedation risk Abrupt discontinuation can cause withdrawal symptoms.

Benzodiazepine

avoid

CLOBAZAM

Comprehensive clinical and safety monograph for CLOBAZAM (CLOBAZAM).

Benzodiazepine

caution

CLONAZEPAM

CNS depressants including alcohol and opioids increase sedation risk Abrupt discontinuation can cause withdrawal seizures.

Benzodiazepine

avoid

CLORAZEPATE DIPOTASSIUM

CNS depressants including alcohol and opioids increase sedation risk Abrupt discontinuation can cause withdrawal symptoms.

Benzodiazepine

avoid

CLOROTEKAL

Comprehensive clinical and safety monograph for CLOROTEKAL (CLOROTEKAL).

Benzodiazepine Anxiolytic

caution

DALMANE

Comprehensive clinical and safety monograph for DALMANE (DALMANE).

Benzodiazepine Hypnotic

caution

DIASTAT

Comprehensive clinical and safety monograph for DIASTAT (DIASTAT).

Benzodiazepine Anticonvulsant

caution

DIASTAT ACUDIAL

Comprehensive clinical and safety monograph for DIASTAT ACUDIAL (DIASTAT ACUDIAL).

Benzodiazepine Anticonvulsant

caution

DIAZEPAM

CNS depressants including alcohol and opioids increase sedation risk Abrupt discontinuation can cause withdrawal symptoms.

Benzodiazepine

avoid

DIAZEPAM INTENSOL

CNS depressants including alcohol and opioids increase sedation risk Abrupt discontinuation can cause withdrawal symptoms.

Benzodiazepine

avoid

DIZAC

Comprehensive clinical and safety monograph for DIZAC (DIZAC).

Benzodiazepine

caution

DORAL

Comprehensive clinical and safety monograph for DORAL (DORAL).

Benzodiazepine

caution

ESTAZOLAM

CNS depressants including alcohol and opioids increase sedation risk Abrupt discontinuation can cause withdrawal symptoms.

Benzodiazepine

avoid

ESZOPICLONE

CNS depressants including alcohol increase sedation risk May cause complex sleep behaviors like sleep-driving.

Non-Benzodiazepine Hypnotic

safe

FLUMAZENIL

Can precipitate acute withdrawal in patients dependent on benzodiazepines Seizures may occur especially in patients on long-term benzodiazepines.

Benzodiazepine Antagonist

safe

FLURAZEPAM HYDROCHLORIDE

CNS depressants including alcohol and opioids increase sedation risk Abrupt discontinuation can cause withdrawal symptoms.

Benzodiazepine

avoid

FOVANE

Comprehensive clinical and safety monograph for FOVANE (FOVANE).

Benzodiazepine

caution

GEN-XENE

Comprehensive clinical and safety monograph for GEN-XENE (GEN-XENE).

Benzodiazepine Anxiolytic

caution

HALCION

Comprehensive clinical and safety monograph for HALCION (HALCION).

Benzodiazepine

caution

INTERMEZZO

Comprehensive clinical and safety monograph for INTERMEZZO (INTERMEZZO).

Nonbenzodiazepine Hypnotic

caution

KLONOPIN

Comprehensive clinical and safety monograph for KLONOPIN (KLONOPIN).

Benzodiazepine

caution

KLONOPIN RAPIDLY DISINTEGRATING

Comprehensive clinical and safety monograph for KLONOPIN RAPIDLY DISINTEGRATING (KLONOPIN RAPIDLY DISINTEGRATING).

Benzodiazepine

caution

LIBERVANT

Comprehensive clinical and safety monograph for LIBERVANT (LIBERVANT).

Benzodiazepine

caution

LIBRELEASE

Comprehensive clinical and safety monograph for LIBRELEASE (LIBRELEASE).

Benzodiazepine

caution

LIBRITABS

Comprehensive clinical and safety monograph for LIBRITABS (LIBRITABS).

Benzodiazepine

caution

LIBRIUM

Comprehensive clinical and safety monograph for LIBRIUM (LIBRIUM).

Benzodiazepine

caution

LIMBITROL

Comprehensive clinical and safety monograph for LIMBITROL (LIMBITROL).

Benzodiazepine/Tricyclic Antidepressant Combination

caution

LIMBITROL DS

Comprehensive clinical and safety monograph for LIMBITROL DS (LIMBITROL DS).

Benzodiazepine/Tricyclic Antidepressant Combination

caution

LORAZ

Comprehensive clinical and safety monograph for LORAZ (LORAZ).

Benzodiazepine

caution

LORAZEPAM

CNS depressants including alcohol and opioids increase sedation risk Abrupt discontinuation can cause withdrawal symptoms.

Benzodiazepine

avoid

LORAZEPAM INTENSOL

CNS depressants including alcohol and opioids increase sedation risk Abrupt discontinuation can cause withdrawal symptoms.

Benzodiazepine

avoid

LORAZEPAM PRESERVATIVE FREE

CNS depressants including alcohol and opioids increase sedation risk Abrupt discontinuation can cause withdrawal symptoms.

Benzodiazepine

avoid

LOREEV XR

Comprehensive clinical and safety monograph for LOREEV XR (LOREEV XR).

Benzodiazepine

caution

LUNESTA

Comprehensive clinical and safety monograph for LUNESTA (LUNESTA).

Non-Benzodiazepine Hypnotic

caution

MENRIUM 10-4

Comprehensive clinical and safety monograph for MENRIUM 10-4 (MENRIUM 10-4).

Benzodiazepine/Estrogen Combination

caution

MENRIUM 5-2

Comprehensive clinical and safety monograph for MENRIUM 5-2 (MENRIUM 5-2).

Benzodiazepine/Estrogen Combination

caution

MENRIUM 5-4

Comprehensive clinical and safety monograph for MENRIUM 5-4 (MENRIUM 5-4).

Benzodiazepine/Estrogen Combination

caution

MIDAZOLAM

CNS depressants including alcohol and opioids increase sedation risk Can cause profound respiratory depression and hypotension.

Benzodiazepine

avoid

MIDAZOLAM HYDROCHLORIDE

CNS depressants including alcohol and opioids increase sedation risk Can cause profound respiratory depression and hypotension.

Benzodiazepine

avoid

MIDAZOLAM HYDROCHLORIDE (AUTOINJECTOR)

CNS depressants including alcohol and opioids increase sedation risk Can cause profound respiratory depression and hypotension.

Benzodiazepine

avoid

MIDAZOLAM HYDROCHLORIDE PRESERVATIVE FREE

CNS depressants including alcohol and opioids increase sedation risk Can cause profound respiratory depression and hypotension.

Benzodiazepine

avoid

MIDOZALAM HYDROCHLORIDE

Comprehensive clinical and safety monograph for MIDOZALAM HYDROCHLORIDE (MIDOZALAM HYDROCHLORIDE).

Benzodiazepine

caution

NAYZILAM

Comprehensive clinical and safety monograph for NAYZILAM (NAYZILAM).

Benzodiazepine

caution

NIRAVAM

Comprehensive clinical and safety monograph for NIRAVAM (NIRAVAM).

Benzodiazepine

caution

ONFI

Comprehensive clinical and safety monograph for ONFI (ONFI).

Benzodiazepine Anticonvulsant

caution

ORAVERSE

Comprehensive clinical and safety monograph for ORAVERSE (ORAVERSE).

Benzodiazepine Antagonist

caution

OXAZEPAM

CNS depressants including alcohol and opioids increase sedation risk Abrupt discontinuation can cause withdrawal symptoms.

Benzodiazepine

avoid

PAXIPAM

Comprehensive clinical and safety monograph for PAXIPAM (PAXIPAM).

Benzodiazepine

caution

PRAZEPAM

Comprehensive clinical and safety monograph for PRAZEPAM (PRAZEPAM).

Benzodiazepine

caution

PROSOM

Comprehensive clinical and safety monograph for PROSOM (PROSOM).

Benzodiazepine Hypnotic

caution

RESTORIL

Comprehensive clinical and safety monograph for RESTORIL (RESTORIL).

Benzodiazepine Hypnotic

caution

ROMAZICON

Comprehensive clinical and safety monograph for ROMAZICON (ROMAZICON).

Benzodiazepine Antagonist

caution

SEIZALAM

Comprehensive clinical and safety monograph for SEIZALAM (SEIZALAM).

Benzodiazepine Anticonvulsant

caution

SERAX

Comprehensive clinical and safety monograph for SERAX (SERAX).

Benzodiazepine

caution

SYMPAZAN

Comprehensive clinical and safety monograph for SYMPAZAN (SYMPAZAN).

Benzodiazepine Anticonvulsant

caution

TEMAZ

Comprehensive clinical and safety monograph for TEMAZ (TEMAZ).

Benzodiazepine

caution

TEMAZEPAM

CNS depressants including alcohol and opioids increase sedation risk Abrupt discontinuation can cause withdrawal symptoms.

Benzodiazepine

avoid

TRANXENE

Comprehensive clinical and safety monograph for TRANXENE (TRANXENE).

Benzodiazepine Anxiolytic

caution

TRANXENE SD

Comprehensive clinical and safety monograph for TRANXENE SD (TRANXENE SD).

Benzodiazepine Anxiolytic

caution

TRIAZOLAM

Strong CYP3A4 inhibitors are contraindicated due to risk of profound sedation Can cause anterograde amnesia and severe sedation.

Benzodiazepine

avoid

VALIUM

Comprehensive clinical and safety monograph for VALIUM (VALIUM).

Benzodiazepine

caution

VALTOCO

Comprehensive clinical and safety monograph for VALTOCO (VALTOCO).

Benzodiazepine Anticonvulsant

caution

VERSED

Comprehensive clinical and safety monograph for VERSED (VERSED).

Benzodiazepine

caution

XANAX

Comprehensive clinical and safety monograph for XANAX (XANAX).

Benzodiazepine

caution

XANAX XR

Comprehensive clinical and safety monograph for XANAX XR (XANAX XR).

Benzodiazepine Anxiolytic

caution

ZALEPLON

CNS depressants including alcohol increase sedation risk Can cause complex sleep behaviors like sleep-driving.

Non-Benzodiazepine Hypnotic

safe

ZAXOPAM

Comprehensive clinical and safety monograph for ZAXOPAM (ZAXOPAM).

Benzodiazepine

caution

ZOLPIDEM TARTRATE

CNS depressants including alcohol increase sedation risk Can cause complex sleep behaviors like sleep-driving.

Non-Benzodiazepine Hypnotic

safe

ZOLPIMIST

Comprehensive clinical and safety monograph for ZOLPIMIST (ZOLPIMIST).

Sedative-Hypnotic (Non-benzodiazepine)

caution