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Clinical Notice:OpiCalc is not a substitute for professional clinical judgment. Always verify dosages and guidelines.

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Registry Hub

Therapeutic Classification

biguanide Registry

Clinical reference for biguanide medications. Access safety monographs, dosing adjustments, and drug-drug interactions for all registered brand names and generics in this class.

Registered Medications (biguanide)

This therapeutic registry is dynamically synthesized from professional clinical sources. Listing of a medication does not imply equivalence; refer to individual monographs for head-to-head pharmacological data.

MedicationTherapeutic ClassMaternal Safety

ACTOPLUS MET

Comprehensive clinical and safety monograph for ACTOPLUS MET (ACTOPLUS MET).

Thiazolidinedione/Biguanide Combination

caution

ACTOPLUS MET XR

Comprehensive clinical and safety monograph for ACTOPLUS MET XR (ACTOPLUS MET XR).

Thiazolidinedione/Biguanide Combination

caution

ALOGLIPTIN AND METFORMIN HYDROCHLORIDE

Alcohol and contrast dye can increase risk of lactic acidosis Can cause lactic acidosis a rare but serious metabolic complication.

Biguanide

safe

ALOGLIPTIN; METFORMIN HYDROCHLORIDE

Alcohol and contrast dye can increase risk of lactic acidosis Can cause lactic acidosis a rare but serious metabolic complication.

Biguanide

safe

AVANDAMET

Comprehensive clinical and safety monograph for AVANDAMET (AVANDAMET).

Thiazolidinedione and Biguanide Combination

caution

BILDYOS

Comprehensive clinical and safety monograph for BILDYOS (BILDYOS).

SGLT2 Inhibitor/Biguanide Combination Antidiabetic

caution

CANAGLIFLOZIN; METFORMIN HYDROCHLORIDE

Alcohol and contrast dye can increase risk of lactic acidosis Can cause lactic acidosis a rare but serious metabolic complication.

Biguanide

safe

DAPAGLIFLOZIN AND METFORMIN

Alcohol and contrast dye can increase risk of lactic acidosis Can cause lactic acidosis a rare but serious metabolic complication.

Biguanide

safe

DAPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE

Alcohol and contrast dye can increase risk of lactic acidosis Can cause lactic acidosis a rare but serious metabolic complication.

Biguanide

safe

EMPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE

Alcohol and contrast dye can increase risk of lactic acidosis Can cause lactic acidosis a rare but serious metabolic complication.

Biguanide

safe

EMPAGLIFLOZIN; LINAGLIPTIN; METFORMIN HYDROCHLORIDE

Alcohol and contrast dye can increase risk of lactic acidosis Can cause lactic acidosis a rare but serious metabolic complication.

Biguanide

safe

EMPAGLIFLOZIN;METFORMIN HYDROCHLORIDE

Alcohol and contrast dye can increase risk of lactic acidosis Can cause lactic acidosis a rare but serious metabolic complication.

Biguanide

safe

GLIPIZIDE AND METFORMIN HYDROCHLORIDE

Alcohol and contrast dye can increase risk of lactic acidosis Can cause lactic acidosis a rare but serious metabolic complication.

Biguanide

safe

GLUCOPHAGE

Comprehensive clinical and safety monograph for GLUCOPHAGE (GLUCOPHAGE).

Biguanide Antidiabetic

caution

GLUCOPHAGE XR

Comprehensive clinical and safety monograph for GLUCOPHAGE XR (GLUCOPHAGE XR).

Biguanide Antidiabetic

caution

GLUCOVANCE

Comprehensive clinical and safety monograph for GLUCOVANCE (GLUCOVANCE).

Antidiabetic Combination (Sulfonylurea + Biguanide)

caution

GLUMETZA

Comprehensive clinical and safety monograph for GLUMETZA (GLUMETZA).

Biguanide Antidiabetic

caution

GLYBURIDE AND METFORMIN HYDROCHLORIDE

Alcohol and contrast dye can increase risk of lactic acidosis Can cause lactic acidosis a rare but serious metabolic complication.

Biguanide

safe

GOMEKLI

Comprehensive clinical and safety monograph for GOMEKLI (GOMEKLI).

Biguanide Antidiabetic

caution

INVOKAMET

Comprehensive clinical and safety monograph for INVOKAMET (INVOKAMET).

SGLT2 Inhibitor / Biguanide Combination

caution

INVOKAMET XR

Comprehensive clinical and safety monograph for INVOKAMET XR (INVOKAMET XR).

SGLT2 Inhibitor / Biguanide Combination

caution

JANUMET

Comprehensive clinical and safety monograph for JANUMET (JANUMET).

DPP-4 Inhibitor/Biguanide Combination

caution

JANUMET XR

Comprehensive clinical and safety monograph for JANUMET XR (JANUMET XR).

DPP-4 Inhibitor/Biguanide Combination

caution

JENTADUETO

Comprehensive clinical and safety monograph for JENTADUETO (JENTADUETO).

DPP-4 Inhibitor / Biguanide Combination

caution

JENTADUETO XR

Comprehensive clinical and safety monograph for JENTADUETO XR (JENTADUETO XR).

DPP-4 Inhibitor / Biguanide Combination

caution

KAZANO

Comprehensive clinical and safety monograph for KAZANO (KAZANO).

Antidiabetic Combination (DPP-4 Inhibitor + Biguanide)

caution

KOMBIGLYZE XR

Comprehensive clinical and safety monograph for KOMBIGLYZE XR (KOMBIGLYZE XR).

DPP-4 Inhibitor + Biguanide Combination

caution

LINAGLIPTIN AND METFORMIN HYDROCHLORIDE

Alcohol and contrast dye can increase risk of lactic acidosis Can cause lactic acidosis a rare but serious metabolic complication.

Biguanide

safe

LINAGLIPTIN; METFORMIN HYDROCHLORIDE

Alcohol and contrast dye can increase risk of lactic acidosis Can cause lactic acidosis a rare but serious metabolic complication.

Biguanide

safe

Metformin

Widely used for gestational diabetes mellitus (GDM) and type 2 diabetes in pregnancy. Crosses the placenta, with fetal concentrations approximating maternal concentrations. Despite this, no teratogenicity has been demonstrated in large human studies. Long-term follow-up data (MiG TOFU trial) showed increased childhood adiposity in metformin-exposed offspring; clinical significance is uncertain. Many clinicians use it as adjunct or alternative to insulin for GDM.

Biguanide

safe

METFORMIN HYDROCHLORIDE

Alcohol and contrast dye can increase risk of lactic acidosis Can cause lactic acidosis a rare but serious metabolic complication.

Biguanide

safe

QTERNMET XR

Comprehensive clinical and safety monograph for QTERNMET XR (QTERNMET XR).

Biguanide Antidiabetic

caution

REPAGLINIDE AND METFORMIN HYDROCHLORIDE

Alcohol and contrast dye can increase risk of lactic acidosis Can cause lactic acidosis a rare but serious metabolic complication.

Biguanide

safe

RIOMET

Comprehensive clinical and safety monograph for RIOMET (RIOMET).

Biguanide Antidiabetic

caution

RIOMET ER

Comprehensive clinical and safety monograph for RIOMET ER (RIOMET ER).

Biguanide Antidiabetic

caution

SEGLUROMET

Comprehensive clinical and safety monograph for SEGLUROMET (SEGLUROMET).

SGLT2 Inhibitor/Biguanide Combination

caution