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Registry Hub

Therapeutic Classification

ergot alkaloid Registry

Clinical reference for ergot alkaloid medications. Access safety monographs, dosing adjustments, and drug-drug interactions for all registered brand names and generics in this class.

Registered Medications (ergot alkaloid)

This therapeutic registry is dynamically synthesized from professional clinical sources. Listing of a medication does not imply equivalence; refer to individual monographs for head-to-head pharmacological data.

MedicationTherapeutic ClassMaternal Safety

CAFERGOT

Comprehensive clinical and safety monograph for CAFERGOT (CAFERGOT).

Antimigraine Agent (Ergot Alkaloid)

caution

DIHYDROERGOTAMINE MESYLATE

Strong CYP3A4 inhibitors (eg clarithromycin) are contraindicated due to risk of ergotism Contraindicated in coronary artery disease and uncontrolled hypertension.

Ergot Alkaloid

avoid

ERGOLOID MESYLATES

No significant drug interactions Not for use in the treatment of psychosis or acute mental disorders.

Ergot Alkaloid

safe

ERGOMAR

Comprehensive clinical and safety monograph for ERGOMAR (ERGOMAR).

Ergot Alkaloid Antimigraine

caution

Ergometrine / Methylergonovine

Uterotonic ergot alkaloid used for prevention and treatment of PPH after delivery of the placenta. Effective but has significant contraindications: causes vasoconstriction and is contraindicated in hypertension, preeclampsia, and cardiovascular disease — which are common comorbidities in obstetric PPH scenarios. Oxytocin and misoprostol are preferred first-line agents; ergometrine is reserved for refractory cases or used in combination (Syntometrine = oxytocin + ergometrine). Must not be used before delivery of the baby — severe uterine tetany and fetal hypoxia.

Ergot Alkaloid Uterotonic

caution

ERGOSTAT

Comprehensive clinical and safety monograph for ERGOSTAT (ERGOSTAT).

Ergot Alkaloid Antimigraine

caution

ERGOTAMINE TARTRATE AND CAFFEINE

Strong CYP3A4 inhibitors (eg clarithromycin) are contraindicated due to risk of ergotism Contraindicated in coronary artery disease and uncontrolled hypertension.

Ergot Alkaloid

avoid

HYDERGINE

Comprehensive clinical and safety monograph for HYDERGINE (HYDERGINE).

Ergot Alkaloid

caution

HYDERGINE LC

Comprehensive clinical and safety monograph for HYDERGINE LC (HYDERGINE LC).

Ergot Alkaloid

caution

HYDROGENATED ERGOT ALKALOIDS

Comprehensive clinical and safety monograph for HYDROGENATED ERGOT ALKALOIDS (HYDROGENATED ERGOT ALKALOIDS).

Ergot Alkaloid

caution

MEDIHALER ERGOTAMINE

Strong CYP3A4 inhibitors (eg clarithromycin) are contraindicated due to risk of ergotism Contraindicated in coronary artery disease and uncontrolled hypertension.

Ergot Alkaloid

avoid

METHERGINE

Comprehensive clinical and safety monograph for METHERGINE (METHERGINE).

Ergot Alkaloid Uterotonic

caution

METHYLERGONOVINE MALEATE

Strong CYP3A4 inhibitors are contraindicated due to risk of ergotism Contraindicated in hypertension and coronary artery disease.

Ergot Alkaloid

avoid

MIGERGOT

Comprehensive clinical and safety monograph for MIGERGOT (MIGERGOT).

Ergot Alkaloid

caution

MIGRANAL

Comprehensive clinical and safety monograph for MIGRANAL (MIGRANAL).

Ergot Alkaloid

caution

TRUDHESA

Comprehensive clinical and safety monograph for TRUDHESA (TRUDHESA).

Antimigraine (Ergot Alkaloid)

caution

WIGRAINE

Comprehensive clinical and safety monograph for WIGRAINE (WIGRAINE).

Ergot Alkaloid

caution

WIGRETTES

Comprehensive clinical and safety monograph for WIGRETTES (WIGRETTES).

Ergot Alkaloid

caution