ABEMACICLIB Pregnancy: There are no adequate human studies; abemaciclib is teratogenic in animals. Avoid use during pregnancy; effective contraception required for females of reproductive potential. | Cyclin-dependent kinase inhibitor | caution |
AFATINIB Comprehensive clinical and safety monograph for AFATINIB (AFATINIB). | Tyrosine Kinase Inhibitor Antineoplastic | caution |
ALECENSA Comprehensive clinical and safety monograph for ALECENSA (ALECENSA). | Kinase Inhibitor Antineoplastic | caution |
ALUNBRIG Comprehensive clinical and safety monograph for ALUNBRIG (ALUNBRIG). | Tyrosine Kinase Inhibitor | caution |
AXITINIB Comprehensive clinical and safety monograph for AXITINIB (AXITINIB). | VEGF Receptor Tyrosine Kinase Inhibitor | caution |
AXTLE Comprehensive clinical and safety monograph for AXTLE (AXTLE). | VEGF Receptor Tyrosine Kinase Inhibitor | caution |
AYVAKIT Comprehensive clinical and safety monograph for AYVAKIT (AYVAKIT). | KIT/PDGFRA Tyrosine Kinase Inhibitor | caution |
BOSULIF Comprehensive clinical and safety monograph for BOSULIF (BOSULIF). | Tyrosine Kinase Inhibitor | caution |
BOSUTINIB Comprehensive clinical and safety monograph for BOSUTINIB (BOSUTINIB). | Tyrosine Kinase Inhibitor | caution |
BOSUTINIB MONOHYDRATE Comprehensive clinical and safety monograph for BOSUTINIB MONOHYDRATE (BOSUTINIB MONOHYDRATE). | Tyrosine Kinase Inhibitor | caution |
CABOMETYX Comprehensive clinical and safety monograph for CABOMETYX (CABOMETYX). | Tyrosine Kinase Inhibitor | caution |
CABOZANTINIB Comprehensive clinical and safety monograph for CABOZANTINIB (CABOZANTINIB). | Tyrosine Kinase Inhibitor | caution |
CAPRELSA Comprehensive clinical and safety monograph for CAPRELSA (CAPRELSA). | Kinase Inhibitor | caution |
COMETRIQ Comprehensive clinical and safety monograph for COMETRIQ (COMETRIQ). | Antineoplastic (Multikinase Inhibitor) | caution |
DASATINIB Antacids and H2 blockers decrease absorption May cause severe myelosuppression and fluid retention. | Kinase Inhibitor | avoid |
EXKIVITY Comprehensive clinical and safety monograph for EXKIVITY (EXKIVITY). | Tyrosine Kinase Inhibitor | caution |
GAVRETO Comprehensive clinical and safety monograph for GAVRETO (GAVRETO). | RET Kinase Inhibitor | caution |
GEFITINIB Strong CYP3A4 inducers may decrease efficacy Can cause interstitial lung disease and diarrhea. | Kinase Inhibitor | avoid |
GILOTRIF Comprehensive clinical and safety monograph for GILOTRIF (GILOTRIF). | Tyrosine Kinase Inhibitor | caution |
GLEEVEC Comprehensive clinical and safety monograph for GLEEVEC (GLEEVEC). | Tyrosine Kinase Inhibitor | caution |
IBRANCE Comprehensive clinical and safety monograph for IBRANCE (IBRANCE). | Cyclin-Dependent Kinase Inhibitor | caution |
ICLUSIG Comprehensive clinical and safety monograph for ICLUSIG (ICLUSIG). | Tyrosine Kinase Inhibitor | caution |
IMATINIB MESYLATE Strong CYP3A4 inducers may decrease efficacy Can cause fluid retention and myelosuppression. | Kinase Inhibitor | avoid |
INLYTA Comprehensive clinical and safety monograph for INLYTA (INLYTA). | Tyrosine Kinase Inhibitor | caution |
IRESSA Comprehensive clinical and safety monograph for IRESSA (IRESSA). | EGFR Tyrosine Kinase Inhibitor | caution |
JAKAFI Comprehensive clinical and safety monograph for JAKAFI (JAKAFI). | Janus Kinase Inhibitor | caution |
JASCAYD Comprehensive clinical and safety monograph for JASCAYD (JASCAYD). | Tyrosine Kinase Inhibitor | caution |
LAPATINIB DITOSYLATE Comprehensive clinical and safety monograph for LAPATINIB DITOSYLATE (LAPATINIB DITOSYLATE). | Tyrosine Kinase Inhibitor | caution |
LENVATINIB Comprehensive clinical and safety monograph for LENVATINIB (LENVATINIB). | Tyrosine Kinase Inhibitor | caution |
LENVIMA Comprehensive clinical and safety monograph for LENVIMA (LENVIMA). | Tyrosine Kinase Inhibitor | caution |
LORBRENA Comprehensive clinical and safety monograph for LORBRENA (LORBRENA). | Kinase inhibitor | caution |
LYNKUET Comprehensive clinical and safety monograph for LYNKUET (LYNKUET). | Kinase inhibitor | caution |
LYTGOBI Comprehensive clinical and safety monograph for LYTGOBI (LYTGOBI). | Kinase inhibitor | caution |
MIDOSTAURIN Comprehensive clinical and safety monograph for MIDOSTAURIN (MIDOSTAURIN). | Tyrosine Kinase Inhibitor | caution |
NERATINIB MALEATE Comprehensive clinical and safety monograph for NERATINIB MALEATE (NERATINIB MALEATE). | Tyrosine Kinase Inhibitor | caution |
NERLYNX Comprehensive clinical and safety monograph for NERLYNX (NERLYNX). | Tyrosine Kinase Inhibitor | caution |
NETARSUDIL MESYLATE Comprehensive clinical and safety monograph for NETARSUDIL MESYLATE (NETARSUDIL MESYLATE). | Rho Kinase Inhibitor | caution |
NEXAVAR Comprehensive clinical and safety monograph for NEXAVAR (NEXAVAR). | Tyrosine Kinase Inhibitor | caution |
NILOTINIB Strong CYP3A4 inhibitors may increase levels and inducers may decrease levels Can cause QT prolongation and sudden death. | Kinase Inhibitor | avoid |
NILOTINIB D-TARTRATE Strong CYP3A4 inhibitors may increase levels and inducers may decrease levels Can cause QT prolongation and sudden death. | Kinase Inhibitor | avoid |
NILOTINIB HYDROCHLORIDE Strong CYP3A4 inhibitors may increase levels and inducers may decrease levels Can cause QT prolongation and sudden death. | Kinase Inhibitor | avoid |
NILOTINIB HYDROCHLORIDE DIHYDRATE Strong CYP3A4 inhibitors may increase levels and inducers may decrease levels Can cause QT prolongation and sudden death. | Kinase Inhibitor | avoid |
NINTEDANIB Comprehensive clinical and safety monograph for NINTEDANIB (NINTEDANIB). | Tyrosine Kinase Inhibitor | caution |
NINTEDANIB ESYLATE Comprehensive clinical and safety monograph for NINTEDANIB ESYLATE (NINTEDANIB ESYLATE). | Tyrosine Kinase Inhibitor | caution |
OFEV Comprehensive clinical and safety monograph for OFEV (OFEV). | Tyrosine Kinase Inhibitor | caution |
OGSIVEO Comprehensive clinical and safety monograph for OGSIVEO (OGSIVEO). | Antineoplastic (Multi-kinase Inhibitor) | caution |
OJEMDA Comprehensive clinical and safety monograph for OJEMDA (OJEMDA). | RAF Kinase Inhibitor | caution |
OJJAARA Comprehensive clinical and safety monograph for OJJAARA (OJJAARA). | JAK2 Kinase Inhibitor | caution |
OLUMIANT Comprehensive clinical and safety monograph for OLUMIANT (OLUMIANT). | JAK Kinase Inhibitor | caution |
PAZOPANIB HYDROCHLORIDE Strong CYP3A4 inhibitors may increase levels and inducers may decrease levels Can cause hepatotoxicity and QT prolongation. | Kinase Inhibitor | avoid |
PEMAZYRE Comprehensive clinical and safety monograph for PEMAZYRE (PEMAZYRE). | Kinase Inhibitor | caution |
PONATINIB HYDROCHLORIDE Comprehensive clinical and safety monograph for PONATINIB HYDROCHLORIDE (PONATINIB HYDROCHLORIDE). | Tyrosine Kinase Inhibitor | caution |
PONLIMSI Comprehensive clinical and safety monograph for PONLIMSI (PONLIMSI). | Tyrosine Kinase Inhibitor | caution |
QINLOCK Comprehensive clinical and safety monograph for QINLOCK (QINLOCK). | Tyrosine Kinase Inhibitor | caution |
QLOSI Comprehensive clinical and safety monograph for QLOSI (QLOSI). | Kinase Inhibitor | caution |
REGORAFENIB Strong CYP3A4 inhibitors may increase levels and inducers may decrease levels Can cause severe hepatotoxicity and hemorrhage. | Kinase Inhibitor | avoid |
RETEVMO Comprehensive clinical and safety monograph for RETEVMO (RETEVMO). | Kinase Inhibitor | caution |
REZUROCK Comprehensive clinical and safety monograph for REZUROCK (REZUROCK). | Kinase Inhibitor (FGFR Inhibitor) | caution |
RHOPRESSA Comprehensive clinical and safety monograph for RHOPRESSA (RHOPRESSA). | Rho Kinase Inhibitor | caution |
RHUZDAH Comprehensive clinical and safety monograph for RHUZDAH (RHUZDAH). | Antineoplastic (Kinase Inhibitor) | caution |
ROZLYTREK Comprehensive clinical and safety monograph for ROZLYTREK (ROZLYTREK). | Tyrosine Kinase Inhibitor | caution |
RYDAPT Comprehensive clinical and safety monograph for RYDAPT (RYDAPT). | FLT3 Kinase Inhibitor Antineoplastic | caution |
SCEMBLIX Comprehensive clinical and safety monograph for SCEMBLIX (SCEMBLIX). | Tyrosine Kinase Inhibitor, Antineoplastic | caution |
SORAFENIB TOSYLATE Strong CYP3A4 inducers may decrease efficacy Can cause hand-foot skin reaction and hypertension. | Kinase Inhibitor | avoid |
SPRYCEL Comprehensive clinical and safety monograph for SPRYCEL (SPRYCEL). | Tyrosine Kinase Inhibitor | caution |
STIVARGA Comprehensive clinical and safety monograph for STIVARGA (STIVARGA). | Tyrosine Kinase Inhibitor | caution |
SUNITINIB MALATE Strong CYP3A4 inhibitors may increase levels and inducers may decrease levels Can cause hepatotoxicity and left ventricular dysfunction. | Kinase Inhibitor | avoid |
SUTENT Comprehensive clinical and safety monograph for SUTENT (SUTENT). | Tyrosine Kinase Inhibitor Antineoplastic | caution |
TABRECTA Comprehensive clinical and safety monograph for TABRECTA (TABRECTA). | Kinase inhibitor (MET inhibitor) | caution |
TAFINLAR Comprehensive clinical and safety monograph for TAFINLAR (TAFINLAR). | Kinase inhibitor (BRAF inhibitor) | caution |
TAGRISSO Comprehensive clinical and safety monograph for TAGRISSO (TAGRISSO). | Kinase inhibitor (EGFR inhibitor) | caution |
TARCEVA Comprehensive clinical and safety monograph for TARCEVA (TARCEVA). | EGFR Tyrosine Kinase Inhibitor | caution |
TASIGNA Comprehensive clinical and safety monograph for TASIGNA (TASIGNA). | Tyrosine Kinase Inhibitor | caution |
TEPMETKO Comprehensive clinical and safety monograph for TEPMETKO (TEPMETKO). | Tyrosine Kinase Inhibitor | caution |
TUKYSA Comprehensive clinical and safety monograph for TUKYSA (TUKYSA). | Tyrosine Kinase Inhibitor (HER2-specific) | caution |
TYKERB Comprehensive clinical and safety monograph for TYKERB (TYKERB). | Tyrosine kinase inhibitor | caution |
VITRAKVI Comprehensive clinical and safety monograph for VITRAKVI (VITRAKVI). | Kinase Inhibitor | caution |
VOTRIENT Comprehensive clinical and safety monograph for VOTRIENT (VOTRIENT). | VEGF Receptor Tyrosine Kinase Inhibitor | caution |
XALKORI Comprehensive clinical and safety monograph for XALKORI (XALKORI). | Tyrosine Kinase Inhibitor | caution |
