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Registry Hub

Therapeutic Classification

leukotriene receptor antagonist Registry

Clinical reference for leukotriene receptor antagonist medications. Access safety monographs, dosing adjustments, and drug-drug interactions for all registered brand names and generics in this class.

Registered Medications (leukotriene receptor antagonist)

This therapeutic registry is dynamically synthesized from professional clinical sources. Listing of a medication does not imply equivalence; refer to individual monographs for head-to-head pharmacological data.

MedicationTherapeutic ClassMaternal Safety

ACCOLATE

Comprehensive clinical and safety monograph for ACCOLATE (ACCOLATE).

Leukotriene Receptor Antagonist

caution

Montelukast

Used for asthma and allergic rhinitis. Human pregnancy data are limited but reassuring — no consistent increase in malformations in available cohort studies. The FDA added a boxed warning in 2020 regarding neuropsychiatric events (not pregnancy-specific). Inhaled corticosteroids and beta-agonists remain first-line for asthma in pregnancy; montelukast may be continued if the patient was well-controlled on it prior to pregnancy.

Leukotriene Receptor Antagonist

caution

MONTELUKAST SODIUM

Phenobarbital may decrease levels Can cause neuropsychiatric events including agitation and depression.

Leukotriene Receptor Antagonist

safe

SINGULAIR

Comprehensive clinical and safety monograph for SINGULAIR (SINGULAIR).

Leukotriene receptor antagonist

caution

ZAFIRLUKAST

Warfarin metabolism is inhibited increasing INR Can cause hepatic failure and Churg-Strauss syndrome.

Leukotriene Receptor Antagonist

safe