Therapeutic Classification

leukotriene receptor antagonist Registry

Clinical reference for leukotriene receptor antagonist medications. Access safety monographs, dosing adjustments, and drug-drug interactions for all registered brand names and generics in this class.

Registered Medications (leukotriene receptor antagonist)

Medication	Therapeutic Class	Maternal Safety
Montelukast Used for asthma and allergic rhinitis. Human pregnancy data are limited but reassuring — no consistent increase in malformations in available cohort studies. The FDA added a boxed warning in 2020 regarding neuropsychiatric events (not pregnancy-specific). Inhaled corticosteroids and beta-agonists remain first-line for asthma in pregnancy; montelukast may be continued if the patient was well-controlled on it prior to pregnancy.	Leukotriene Receptor Antagonist	caution
MONTELUKAST SODIUM Phenobarbital may decrease levels Can cause neuropsychiatric events including agitation and depression.	Leukotriene Receptor Antagonist	safe
ZAFIRLUKAST Warfarin metabolism is inhibited increasing INR Can cause hepatic failure and Churg-Strauss syndrome.	Leukotriene Receptor Antagonist	safe

This therapeutic registry is dynamically synthesized from professional clinical sources. Listing of a medication does not imply equivalence; refer to individual monographs for head-to-head pharmacological data.