Comparative Pharmacology
Head-to-head clinical analysis: ACULAR PRESERVATIVE FREE versus ACUVAIL.
Peer-Reviewed Evidence
Head-to-head clinical analysis: ACULAR PRESERVATIVE FREE versus ACUVAIL.
ACULAR PRESERVATIVE FREE vs ACUVAIL
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Ketorolac tromethamine is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing prostaglandin synthesis. It produces anti-inflammatory and analgesic effects.
Ketorolac tromethamine, a nonsteroidal anti-inflammatory drug (NSAID), inhibits prostaglandin synthesis by blocking cyclooxygenase (COX-1 and COX-2) enzymes. This reduces ocular inflammation and pain.
1 drop into affected eye(s) four times daily (every 6 hours). Instill into conjunctival sac. Shake well before use.
1 drop in the affected eye 4 times daily.
None Documented
None Documented
Terminal elimination half-life is approximately 5-6 hours in adults, but can be prolonged in elderly patients (up to 8-9 hours) and in patients with renal impairment (up to 13-19 hours).
Terminal elimination half-life is approximately 46 minutes in the aqueous humor following ocular administration in humans.
Primarily renal excretion of metabolites and unchanged drug; approximately 80% of a dose is excreted in urine as ketorolac and its hydroxy metabolites, with about 6% excreted in feces.
Primarily renal excretion of metabolites; less than 1% excreted unchanged. Biliary/fecal elimination accounts for <10%.
Category C
Category C
NSAID Ophthalmic
NSAID Ophthalmic