Comparative Pharmacology
Head-to-head clinical analysis: ACULAR versus ACULAR PRESERVATIVE FREE.
Peer-Reviewed Evidence
Head-to-head clinical analysis: ACULAR versus ACULAR PRESERVATIVE FREE.
ACULAR vs ACULAR PRESERVATIVE FREE
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis, which decreases inflammation, pain, and fever.
Ketorolac tromethamine is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing prostaglandin synthesis. It produces anti-inflammatory and analgesic effects.
One drop of 0.5% ophthalmic solution into the affected eye(s) four times daily.
1 drop into affected eye(s) four times daily (every 6 hours). Instill into conjunctival sac. Shake well before use.
None Documented
None Documented
Terminal half-life: 1.8 hours (ketorolac tromethamine); clinical context: short half-life supports dosing every 6 hours for acute pain, but prolonged in elderly or renal impairment (↑ to 5-6 hours, thus dose reduction required).
Terminal elimination half-life is approximately 5-6 hours in adults, but can be prolonged in elderly patients (up to 8-9 hours) and in patients with renal impairment (up to 13-19 hours).
Renal: ~80% as unchanged drug and glucuronide conjugates; biliary/fecal: ~20%
Primarily renal excretion of metabolites and unchanged drug; approximately 80% of a dose is excreted in urine as ketorolac and its hydroxy metabolites, with about 6% excreted in feces.
Category C
Category C
NSAID Ophthalmic
NSAID Ophthalmic