Comparative Pharmacology
Head-to-head clinical analysis: ALPROSTADIL versus DURYSTA.
Peer-Reviewed Evidence
Head-to-head clinical analysis: ALPROSTADIL versus DURYSTA.
ALPROSTADIL vs DURYSTA
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Alprostadil is a synthetic prostaglandin E1 (PGE1) that causes vasodilation by binding to prostanoid EP receptors, increasing intracellular cAMP, and relaxing smooth muscle. It also inhibits platelet aggregation.
Prostaglandin analog; selective FP receptor agonist that increases uveoscleral outflow of aqueous humor.
Initial: 20-40 mcg IV bolus over 1-2 seconds; then 30-70 mcg/min continuous IV infusion for erectile dysfunction via intracavernosal injection: 2.5-10 mcg; for patent ductus arteriosus: 0.05-0.1 mcg/kg/min continuous IV infusion.
One intracameral implant (10 mcg) administered in the study eye by a qualified ophthalmologist. A second administration may be performed if necessary, at least 3 months after the initial implant.
None Documented
None Documented
Clinical Note
moderateAlprostadil + Limaprost
"Alprostadil may increase the antiplatelet activities of Limaprost."
Clinical Note
moderateAlprostadil + Epoprostenol
"Alprostadil may increase the antiplatelet activities of Epoprostenol."
Clinical Note
moderateTiaprofenic acid + Alprostadil
"The therapeutic efficacy of Alprostadil can be decreased when used in combination with Tiaprofenic acid."
Clinical Note
moderateCarprofen + Alprostadil
5-10 minutes; rapidly metabolized in the lungs, clinical effect lasts longer due to continuous infusion.
Not applicable due to local ocular administration with minimal systemic exposure; bimatoprost systemic half-life is approximately 45 minutes after intravenous administration.
Primarily via urine (90%) as metabolites; 10% unchanged; minimal fecal excretion.
Minimal systemic absorption; no data on specific routes of elimination; expected to be primarily excreted via renal and biliary routes in small amounts.
Category C
Category C
Prostaglandin Analog
Prostaglandin Analog
"The therapeutic efficacy of Alprostadil can be decreased when used in combination with Carprofen."