Comparative Pharmacology
Head-to-head clinical analysis: AMCILL versus BACTOCILL.
Peer-Reviewed Evidence
Head-to-head clinical analysis: AMCILL versus BACTOCILL.
AMCILL vs BACTOCILL
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Ampicillin is a beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death.
BACTOCILL (nafcillin) is a penicillinase-resistant penicillin that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), thereby inhibiting transpeptidation and autolysin inhibitors. Active against Staphylococcus aureus and other gram-positive bacteria.
250-500 mg orally every 8 hours or 500 mg every 12 hours; for severe infections, up to 1 g every 6 hours intravenously.
250-500 mg orally every 6 hours or 1-2 g intravenously every 4-6 hours
None Documented
None Documented
1-1.5 hours in normal renal function; prolonged to 7-10 hours in anuria.
0.5-0.8 hours; prolonged to 2-4 hours in severe renal impairment
Renal: 60-80% unchanged; biliary: less than 10%; fecal: small amount.
Renal: 60-70% unchanged; biliary: 20-30% as active metabolite; fecal: 5-10%
Category C
Category C
Penicillin Antibiotic
Penicillin Antibiotic