Comparative Pharmacology
Head-to-head clinical analysis: AMINOSYN II 7 versus TRAVASOL 2 75 IN DEXTROSE 10 IN PLASTIC CONTAINER.
Peer-Reviewed Evidence
Head-to-head clinical analysis: AMINOSYN II 7 versus TRAVASOL 2 75 IN DEXTROSE 10 IN PLASTIC CONTAINER.
AMINOSYN II 7% vs TRAVASOL 2.75% IN DEXTROSE 10% IN PLASTIC CONTAINER
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Aminosyn II 7% is a crystalline amino acid solution that provides essential and non-essential amino acids for protein synthesis, tissue repair, and maintenance of nitrogen balance. It acts as a substrate for protein synthesis and supports metabolic functions in patients unable to tolerate oral or enteral nutrition.
Travasol 2.75% in Dextrose 10% provides essential amino acids and caloric support via dextrose. Amino acids serve as substrates for protein synthesis and nitrogen balance, while dextrose provides glucose for energy metabolism. The combination is used for parenteral nutrition to maintain or restore positive nitrogen balance in patients unable to tolerate enteral nutrition.
Intravenous infusion; typical adult dose: 0.8-1.5 g amino acids/kg/day (11.4-21.4 mL/kg/day of 7% solution); rate not exceeding 0.1 g amino acids/kg/hour.
Intravenous infusion. 1000 mL to 3000 mL per day, typically infused at 1.2-1.5 g amino acids/kg/day; adjust based on metabolic needs and fluid status.
None Documented
None Documented
Not applicable; exogenous amino acids are rapidly cleared from plasma with a terminal half-life of 15-20 minutes for individual amino acids.
Not applicable as a single entity. Components are endogenous substances. Dextrose has a half-life of minutes due to rapid insulin-mediated uptake. Amino acids have variable half-lives (minutes to hours) depending on individual amino acid and metabolic state.
Renal as amino acids and metabolites; negligible biliary/fecal.
TRAVASOL 2.75% IN DEXTROSE 10% is a combination of amino acids and dextrose. The amino acids are primarily metabolized and the nitrogen is excreted as urea in urine (renal, >90%). Dextrose is metabolized to CO2 and water; negligible biliary/fecal excretion.
Category C
Category C
Amino Acid Solution
Amino Acid Solution