Comparative Pharmacology
Head-to-head clinical analysis: AMOXICILLIN versus AUGMENTIN 500.
Peer-Reviewed Evidence
Head-to-head clinical analysis: AMOXICILLIN versus AUGMENTIN 500.
AMOXICILLIN vs AUGMENTIN '500'
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Amoxicillin is a beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting transpeptidase activity, and activating autolytic enzymes.
Amoxicillin is a semisynthetic aminopenicillin that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting transpeptidation and disrupting cell wall integrity, leading to bacteriolysis. Clavulanate is a beta-lactamase inhibitor that irreversibly binds to and inactivates a broad range of beta-lactamases, preventing degradation of amoxicillin and extending its spectrum to include beta-lactamase-producing bacteria.
250-500 mg orally every 8 hours or 500-875 mg orally every 12 hours; for severe infections, up to 1 g orally every 8 hours.
1 tablet (amoxicillin 500 mg / clavulanate 125 mg) orally every 8 hours or 1 tablet (amoxicillin 875 mg / clavulanate 125 mg) orally every 12 hours for mild to moderate infections. For severe infections, use 875 mg/125 mg every 12 hours.
None Documented
None Documented
Clinical Note
moderateAmoxicillin + Acemetacin
"Amoxicillin may decrease the excretion rate of Acemetacin which could result in a higher serum level."
Clinical Note
moderateAmoxicillin + Probenecid
"The serum concentration of Probenecid can be increased when it is combined with Amoxicillin."
Clinical Note
moderateAmoxicillin + Fluconazole
"The metabolism of Fluconazole can be decreased when combined with Amoxicillin."
Clinical Note
moderateAmoxicillin + Clotrimazole
Terminal elimination half-life: 1-1.5 hours in normal renal function. Prolonged to 7-20 hours in end-stage renal disease.
Amoxicillin: 1-1.3 hours; clavulanate: 1 hour. In renal impairment (CrCl <30 mL/min): amoxicillin 7-20 hours, clavulanate 4-6 hours. Extends dosing interval.
Renal: 60-80% unchanged via glomerular filtration and tubular secretion. Biliary: up to 20% excreted in bile. Fecal: minimal.
Renal excretion 50-70% (amoxicillin) and 40-60% (clavulanate) as unchanged drug; tubular secretion and glomerular filtration. Fecal elimination <10%.
Category A/B
Category C
Penicillin Antibiotic
Penicillin Antibiotic
"The metabolism of Clotrimazole can be decreased when combined with Amoxicillin."