Comparative Pharmacology
Head-to-head clinical analysis: AMPICILLIN versus DYNAPEN.
Peer-Reviewed Evidence
Head-to-head clinical analysis: AMPICILLIN versus DYNAPEN.
Ampicillin vs DYNAPEN
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Ampicillin is a penicillin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting transpeptidase activity, and disrupting peptidoglycan cross-linking.
Dynapen (dicloxacillin) is a penicillinase-resistant penicillin that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death.
250-500 mg orally every 6 hours; 1-2 g IV/IM every 4-6 hours.
250-500 mg orally every 6 hours for skin and soft tissue infections; up to 500 mg every 6 hours for respiratory tract infections.
None Documented
None Documented
Terminal elimination half-life: 1-1.8 hours in adults with normal renal function; prolonged to 7-20 hours in end-stage renal disease (CrCl <10 mL/min).
Clinical Note
moderateAmpicillin + Acemetacin
"Ampicillin may decrease the excretion rate of Acemetacin which could result in a higher serum level."
Clinical Note
moderateAmpicillin + Probenecid
"The serum concentration of Probenecid can be increased when it is combined with Ampicillin."
Clinical Note
moderateBacampicillin + Probenecid
"The serum concentration of Probenecid can be increased when it is combined with Bacampicillin."
Clinical Note
moderatePivampicillin + Probenecid
0.5-1 hour in normal renal function; prolonged to 7-10 hours in anuria.
Renal: 90% unchanged via glomerular filtration and tubular secretion; biliary: 10% (small amount).
Renal: 60-80% as unchanged drug via glomerular filtration and tubular secretion; biliary/fecal: <10%.
Category A/B
Category C
Penicillin Antibiotic
Penicillin Antibiotic
"The serum concentration of Probenecid can be increased when it is combined with Pivampicillin."