Comparative Pharmacology
Head-to-head clinical analysis: AMPICILLIN versus PIPERACILLIN AND TAZOBACTAM.
Peer-Reviewed Evidence
Head-to-head clinical analysis: AMPICILLIN versus PIPERACILLIN AND TAZOBACTAM.
Ampicillin vs PIPERACILLIN AND TAZOBACTAM
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Ampicillin is a penicillin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting transpeptidase activity, and disrupting peptidoglycan cross-linking.
Piperacillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), while tazobactam is a beta-lactamase inhibitor that protects piperacillin from degradation by beta-lactamases.
250-500 mg orally every 6 hours; 1-2 g IV/IM every 4-6 hours.
3.375 g (piperacillin 3 g + tazobactam 0.375 g) IV every 6 hours, or 4.5 g (piperacillin 4 g + tazobactam 0.5 g) IV every 8 hours for nosocomial pneumonia.
None Documented
None Documented
Clinical Note
moderateAmpicillin + Acemetacin
"Ampicillin may decrease the excretion rate of Acemetacin which could result in a higher serum level."
Clinical Note
moderateAmpicillin + Probenecid
"The serum concentration of Probenecid can be increased when it is combined with Ampicillin."
Clinical Note
moderateBacampicillin + Probenecid
"The serum concentration of Probenecid can be increased when it is combined with Bacampicillin."
Clinical Note
moderatePivampicillin + Probenecid
Terminal elimination half-life: 1-1.8 hours in adults with normal renal function; prolonged to 7-20 hours in end-stage renal disease (CrCl <10 mL/min).
Piperacillin ~0.7–1.2 h, tazobactam ~0.7–1.5 h; prolonged in renal impairment (piperacillin up to 3.3 h, tazobactam up to 5.6 h in severe impairment).
Renal: 90% unchanged via glomerular filtration and tubular secretion; biliary: 10% (small amount).
Primarily renal: piperacillin ~68% unchanged, tazobactam ~80% unchanged; biliary excretion <10%; fecal <1%.
Category A/B
Category C
Penicillin Antibiotic
Penicillin Antibiotic / Beta-Lactamase Inhibitor Combination
"The serum concentration of Probenecid can be increased when it is combined with Pivampicillin."