Comparative Pharmacology
Head-to-head clinical analysis: AMPICILLIN versus PYOPEN.
Peer-Reviewed Evidence
Head-to-head clinical analysis: AMPICILLIN versus PYOPEN.
Ampicillin vs PYOPEN
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Ampicillin is a penicillin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting transpeptidase activity, and disrupting peptidoglycan cross-linking.
Carbenicillin is a bactericidal penicillin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), disrupting peptidoglycan cross-linking.
250-500 mg orally every 6 hours; 1-2 g IV/IM every 4-6 hours.
4 g intravenously every 4 hours.
None Documented
None Documented
Terminal elimination half-life: 1-1.8 hours in adults with normal renal function; prolonged to 7-20 hours in end-stage renal disease (CrCl <10 mL/min).
Clinical Note
moderateAmpicillin + Acemetacin
"Ampicillin may decrease the excretion rate of Acemetacin which could result in a higher serum level."
Clinical Note
moderateAmpicillin + Probenecid
"The serum concentration of Probenecid can be increased when it is combined with Ampicillin."
Clinical Note
moderateBacampicillin + Probenecid
"The serum concentration of Probenecid can be increased when it is combined with Bacampicillin."
Clinical Note
moderatePivampicillin + Probenecid
30-60 minutes in normal renal function; prolonged to 2-4 hours in moderate renal impairment (CrCl 10-30 mL/min) and up to 10 hours in severe renal failure.
Renal: 90% unchanged via glomerular filtration and tubular secretion; biliary: 10% (small amount).
Primarily renal (60-90% unchanged via glomerular filtration and tubular secretion); small amounts biliary (10-30%) and fecal (<10%).
Category A/B
Category C
Penicillin Antibiotic
Penicillin Antibiotic
"The serum concentration of Probenecid can be increased when it is combined with Pivampicillin."