Comparative Pharmacology
Head-to-head clinical analysis: ANTARA MICRONIZED versus FENOFIBRATE.
Peer-Reviewed Evidence
Head-to-head clinical analysis: ANTARA MICRONIZED versus FENOFIBRATE.
ANTARA (MICRONIZED) vs FENOFIBRATE
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Fenofibrate, a fibric acid derivative, activates peroxisome proliferator-activated receptor alpha (PPARα). This leads to increased lipolysis and elimination of triglyceride-rich particles from plasma by inducing lipoprotein lipase activity and reducing production of apolipoprotein C-III.
Fenofibrate is a peroxisome proliferator-activated receptor alpha (PPARα) agonist. It increases lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing production of apolipoprotein C-III.
Oral: 130 mg once daily with or without food. Capsules should be swallowed whole; do not crush or chew.
Fenofibrate: 48-145 mg orally once daily. For fenofibric acid: 45-135 mg orally once daily. Capsules should be taken with meals.
None Documented
None Documented
Terminal elimination half-life is approximately 15–17 hours (range 13–22 hours) in normolipidemic subjects; in hypertriglyceridemic patients, half-life may be prolonged up to 24–33 hours due to increased volume of distribution. Repeated dosing leads to steady state by about 4–5 days.
Terminal elimination half-life of fenofibric acid is approximately 20 hours (range 16-25 hours), allowing once-daily dosing. Steady-state is reached within 5 days.
Renal (approximately 70% of a dose is excreted in the urine, primarily as the glucuronide conjugate; less than 10% is excreted as unchanged drug in urine); fecal/biliary elimination accounts for about 20% (mainly as unchanged drug and metabolites via bile).
Renal: approximately 60% of the dose as fenofibric acid glucuronide; unchanged fenofibric acid < 10%. Biliary/fecal: approximately 25% as fenofibric acid and conjugates. Renal excretion is predominant.
Category C
Category A/B
Fibrate
Fibrate