Comparative Pharmacology
Head-to-head clinical analysis: ASCOR versus FOLICET.
Peer-Reviewed Evidence
Head-to-head clinical analysis: ASCOR versus FOLICET.
ASCOR vs FOLICET
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Ascorbic acid (vitamin C) acts as an antioxidant and a cofactor for several enzymes involved in collagen synthesis, carnitine biosynthesis, and neurotransmitter synthesis. It facilitates iron absorption from the gastrointestinal tract and participates in immune function.
Folic acid is reduced to tetrahydrofolate (THF) through the enzyme dihydrofolate reductase. THF is a cofactor in one-carbon transfer reactions involved in purine and pyrimidine synthesis, and amino acid metabolism, essential for DNA synthesis and cell division.
1 tablet (75 mg) orally once daily for antiplatelet effect; for acute coronary syndrome: initial dose 300 mg orally, then 75 mg orally once daily.
1 mg orally once daily. For treatment of megaloblastic anemia, up to 5 mg daily initially.
None Documented
None Documented
Clinical Note
moderateAscorbic acid + Cyclosporine
"The serum concentration of Cyclosporine can be decreased when it is combined with Ascorbic acid."
Clinical Note
moderateAscorbic acid + Bortezomib
"The therapeutic efficacy of Bortezomib can be decreased when used in combination with Ascorbic acid."
Clinical Note
moderateAscorbic acid + Benzphetamine
"The serum concentration of Benzphetamine can be decreased when it is combined with Ascorbic acid."
Clinical Note
moderateAscorbic acid + Amphetamine
Terminal elimination half-life is 8-12 hours in patients with normal renal function; prolonged to 24-48 hours in renal impairment, requiring dose adjustment.
Terminal elimination half-life is 3-5 hours in adults with normal renal function; may be prolonged up to 12-24 hours in severe renal impairment (CrCl <30 mL/min).
Renal: 70-90% (as unchanged drug and metabolites), biliary/fecal: minor (<10%)
Primarily renal elimination: approximately 80% of the dose is excreted unchanged in urine via glomerular filtration and active tubular secretion. Biliary/fecal excretion accounts for <15%.
Category C
Category C
Vitamin
Vitamin
"The serum concentration of Amphetamine can be decreased when it is combined with Ascorbic acid."