Comparative Pharmacology
Head-to-head clinical analysis: ASCOR versus FOLVITE.
Peer-Reviewed Evidence
Head-to-head clinical analysis: ASCOR versus FOLVITE.
ASCOR vs FOLVITE
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Ascorbic acid (vitamin C) acts as an antioxidant and a cofactor for several enzymes involved in collagen synthesis, carnitine biosynthesis, and neurotransmitter synthesis. It facilitates iron absorption from the gastrointestinal tract and participates in immune function.
Folate is reduced to tetrahydrofolate (THF) which acts as a cofactor for single-carbon transfer reactions in nucleic acid and amino acid synthesis.
1 tablet (75 mg) orally once daily for antiplatelet effect; for acute coronary syndrome: initial dose 300 mg orally, then 75 mg orally once daily.
1 mg orally, intramuscularly, subcutaneously, or intravenously once daily for folic acid deficiency; for pregnant and lactating women: 0.4-0.8 mg orally once daily.
None Documented
None Documented
Clinical Note
moderateAscorbic acid + Cyclosporine
"The serum concentration of Cyclosporine can be decreased when it is combined with Ascorbic acid."
Clinical Note
moderateAscorbic acid + Bortezomib
"The therapeutic efficacy of Bortezomib can be decreased when used in combination with Ascorbic acid."
Clinical Note
moderateAscorbic acid + Benzphetamine
"The serum concentration of Benzphetamine can be decreased when it is combined with Ascorbic acid."
Clinical Note
moderateAscorbic acid + Amphetamine
Terminal elimination half-life is 8-12 hours in patients with normal renal function; prolonged to 24-48 hours in renal impairment, requiring dose adjustment.
Terminal elimination half-life of folic acid is approximately 0.7 hours; for the active metabolite 5-methyltetrahydrofolate, half-life is 3–4 hours in plasma (tissue stores have a much longer turnover).
Renal: 70-90% (as unchanged drug and metabolites), biliary/fecal: minor (<10%)
Primarily excreted unchanged in urine (hepatic metabolism minimal); after oral doses, fecal excretion occurs via unabsorbed drug and biliary secretion of folate metabolites accounts for a minor route.
Category C
Category C
Vitamin
Vitamin
"The serum concentration of Amphetamine can be decreased when it is combined with Ascorbic acid."