Comparative Pharmacology
Head-to-head clinical analysis: ASCOR versus THIAMINE HYDROCHLORIDE.
Peer-Reviewed Evidence
Head-to-head clinical analysis: ASCOR versus THIAMINE HYDROCHLORIDE.
ASCOR vs THIAMINE HYDROCHLORIDE
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Ascorbic acid (vitamin C) acts as an antioxidant and a cofactor for several enzymes involved in collagen synthesis, carnitine biosynthesis, and neurotransmitter synthesis. It facilitates iron absorption from the gastrointestinal tract and participates in immune function.
Thiamine hydrochloride is a water-soluble vitamin that acts as a cofactor for several enzymes involved in carbohydrate metabolism, including transketolase, pyruvate dehydrogenase, and α-ketoglutarate dehydrogenase. It is essential for the decarboxylation of α-keto acids and pentose phosphate pathway activity.
1 tablet (75 mg) orally once daily for antiplatelet effect; for acute coronary syndrome: initial dose 300 mg orally, then 75 mg orally once daily.
50-100 mg intravenously or intramuscularly once daily for deficiency; 100 mg intravenously for Wernicke encephalopathy (with 50-100 mg maintenance).
None Documented
None Documented
Clinical Note
moderateAscorbic acid + Cyclosporine
"The serum concentration of Cyclosporine can be decreased when it is combined with Ascorbic acid."
Clinical Note
moderateAscorbic acid + Bortezomib
"The therapeutic efficacy of Bortezomib can be decreased when used in combination with Ascorbic acid."
Clinical Note
moderateAscorbic acid + Benzphetamine
"The serum concentration of Benzphetamine can be decreased when it is combined with Ascorbic acid."
Clinical Note
moderateAscorbic acid + Amphetamine
Terminal elimination half-life is 8-12 hours in patients with normal renal function; prolonged to 24-48 hours in renal impairment, requiring dose adjustment.
Terminal half-life: 9-18 days for whole body stores; plasma half-life: 1.5-2 hours for free thiamine.
Renal: 70-90% (as unchanged drug and metabolites), biliary/fecal: minor (<10%)
Renal: 40-50% as unchanged drug; metabolites: thiamine pyrophosphate, thiamine monophosphate. Fecal: minimal (<5%).
Category C
Category C
Vitamin
Vitamin
"The serum concentration of Amphetamine can be decreased when it is combined with Ascorbic acid."