Comparative Pharmacology
Head-to-head clinical analysis: AUGMENTIN XR versus BICILLIN C R 900 300.
Peer-Reviewed Evidence
Head-to-head clinical analysis: AUGMENTIN XR versus BICILLIN C R 900 300.
AUGMENTIN XR vs BICILLIN C-R 900/300
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Amoxicillin is a beta-lactam antibacterial that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). Clavulanate is a beta-lactamase inhibitor that irreversibly binds to and inactivates beta-lactamase enzymes, protecting amoxicillin from degradation.
Penicillin G benzathine and penicillin G procaine are beta-lactam antibiotics that inhibit bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), disrupting peptidoglycan cross-linking, leading to cell lysis via autolytic enzymes. Synergistic action covers both susceptible Gram-positive cocci (e.g., Streptococcus pyogenes) and some Gram-negative cocci (e.g., Neisseria spp.).
Adults and adolescents ≥16 years: 2 tablets (amoxicillin 1000 mg/clavulanate 62.5 mg per tablet) orally every 12 hours for 10 days.
Intramuscular injection: 1.2 mL (900,000 units penicillin G benzathine and 300,000 units penicillin G procaine) every 48 hours for 3 doses; for severe infections, up to 2.4 mL (1,800,000/600,000 units) as a single dose.
None Documented
None Documented
Amoxicillin: ~1.0-1.3 hours; clavulanate: ~0.9-1.2 hours; prolonged in renal impairment (creatinine clearance <30 mL/min: amoxicillin half-life up to 7-14 hours).
0.5-1 hour for penicillin G; prolonged to 3-6 hours in renal impairment. Procaine component has no significant effect on elimination half-life
Amoxicillin: ~50-70% excreted unchanged in urine via glomerular filtration and tubular secretion; clavulanate: ~25-40% excreted unchanged in urine; both undergo minor biliary/fecal elimination (<10%).
Renal: 60-90% as unchanged drug; biliary/fecal: minor (less than 10%)
Category C
Category C
Penicillin Antibiotic
Penicillin Antibiotic