Comparative Pharmacology
Head-to-head clinical analysis: AURYXIA versus LANTHANUM CARBONATE.
Peer-Reviewed Evidence
Head-to-head clinical analysis: AURYXIA versus LANTHANUM CARBONATE.
AURYXIA vs LANTHANUM CARBONATE
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
AURYXIA (ferric citrate) is a phosphate binder that reduces serum phosphate by binding dietary phosphate in the gastrointestinal tract, forming insoluble ferric phosphate complexes that are excreted in the feces. The iron component also increases serum iron parameters and may improve iron stores.
Lanthanum carbonate dissociates in the acidic gastric environment to release lanthanum ions, which bind to dietary phosphate in the gastrointestinal tract, forming insoluble lanthanum-phosphate complexes that are excreted in feces, reducing serum phosphate levels.
Adult: 1 tablet (1700 mg ferric citrate) three times daily with meals, titrated every 2-4 weeks to achieve target serum phosphate levels. Maximum dose: 12 tablets per day.
Oral: 500-1000 mg three times daily with meals, titrated based on serum phosphate levels; maximum 3000 mg/day.
None Documented
None Documented
Clinical Note
moderateLanthanum carbonate + Gatifloxacin
"The serum concentration of Gatifloxacin can be decreased when it is combined with Lanthanum carbonate."
Clinical Note
moderateLanthanum carbonate + Rosoxacin
"The serum concentration of Rosoxacin can be decreased when it is combined with Lanthanum carbonate."
Clinical Note
moderateLanthanum carbonate + Levofloxacin
"The serum concentration of Levofloxacin can be decreased when it is combined with Lanthanum carbonate."
Clinical Note
moderateNot applicable; systemic absorption is minimal. AURYXIA is not absorbed and acts locally in the GI tract.
Terminal half-life not clinically defined due to minimal systemic absorption; effectively acts locally in GI tract.
Primarily fecal as unabsorbed drug (≥99%). Renal excretion is negligible (<1%).
Primarily fecal (>99%) as unabsorbed drug. Minimal renal elimination (<1%).
Category C
Category C
Phosphate Binder
Phosphate Binder
Lanthanum carbonate + Trovafloxacin
"The serum concentration of Trovafloxacin can be decreased when it is combined with Lanthanum carbonate."