Comparative Pharmacology
Head-to-head clinical analysis: BACTOCILL versus OXACILLIN SODIUM.
Peer-Reviewed Evidence
Head-to-head clinical analysis: BACTOCILL versus OXACILLIN SODIUM.
BACTOCILL vs OXACILLIN SODIUM
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
BACTOCILL (nafcillin) is a penicillinase-resistant penicillin that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), thereby inhibiting transpeptidation and autolysin inhibitors. Active against Staphylococcus aureus and other gram-positive bacteria.
Oxacillin is a penicillinase-resistant beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), thereby blocking the transpeptidation step in peptidoglycan cross-linking. It is resistant to staphylococcal beta-lactamase.
250-500 mg orally every 6 hours or 1-2 g intravenously every 4-6 hours
1-2 grams IV every 4-6 hours.
None Documented
None Documented
0.5-0.8 hours; prolonged to 2-4 hours in severe renal impairment
0.3-0.8 hours in adults with normal renal function; prolonged to 1-2 hours in neonates and 2-5 hours in patients with severe renal impairment (CrCl <10 mL/min)
Renal: 60-70% unchanged; biliary: 20-30% as active metabolite; fecal: 5-10%
Renal (70-80% unchanged by tubular secretion and glomerular filtration); biliary (minor, approximately 10%)
Category C
Category A/B
Penicillin Antibiotic
Penicillin Antibiotic