Comparative Pharmacology
Head-to-head clinical analysis: BACTOCILL versus PENICILLIN G POTASSIUM IN PLASTIC CONTAINER.
Peer-Reviewed Evidence
Head-to-head clinical analysis: BACTOCILL versus PENICILLIN G POTASSIUM IN PLASTIC CONTAINER.
BACTOCILL vs PENICILLIN G POTASSIUM IN PLASTIC CONTAINER
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
BACTOCILL (nafcillin) is a penicillinase-resistant penicillin that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), thereby inhibiting transpeptidation and autolysin inhibitors. Active against Staphylococcus aureus and other gram-positive bacteria.
Penicillin G is a beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting transpeptidation and activating autolytic enzymes.
250-500 mg orally every 6 hours or 1-2 g intravenously every 4-6 hours
2-4 million units IV every 4 hours for moderate to severe infections; up to 24 million units/day for serious infections (meningitis, endocarditis).
None Documented
None Documented
0.5-0.8 hours; prolonged to 2-4 hours in severe renal impairment
0.5–1 hour (normal renal function). Prolonged in renal impairment (up to 7–10 hours in anuria).
Renal: 60-70% unchanged; biliary: 20-30% as active metabolite; fecal: 5-10%
Renal: 60–90% unchanged via tubular secretion and glomerular filtration. Biliary/fecal: <10%.
Category C
Category A/B
Penicillin Antibiotic
Penicillin Antibiotic