Comparative Pharmacology
Head-to-head clinical analysis: BACTOCILL versus PENTIDS 800.
Peer-Reviewed Evidence
Head-to-head clinical analysis: BACTOCILL versus PENTIDS 800.
BACTOCILL vs PENTIDS '800'
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
BACTOCILL (nafcillin) is a penicillinase-resistant penicillin that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), thereby inhibiting transpeptidation and autolysin inhibitors. Active against Staphylococcus aureus and other gram-positive bacteria.
Penicillin G is a beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), transpeptidases that catalyze the final transpeptidation step of peptidoglycan cross-linking, leading to cell lysis.
250-500 mg orally every 6 hours or 1-2 g intravenously every 4-6 hours
800 mg orally every 6 to 8 hours; maximum 4 g per day.
None Documented
None Documented
0.5-0.8 hours; prolonged to 2-4 hours in severe renal impairment
0.5-1 hour; prolonged to 2-5 hours in renal impairment.
Renal: 60-70% unchanged; biliary: 20-30% as active metabolite; fecal: 5-10%
Renal: ~60-85% unchanged via glomerular filtration and tubular secretion; Biliary: ~10%; Fecal: <5%.
Category C
Category C
Penicillin Antibiotic
Penicillin Antibiotic