Comparative Pharmacology
Head-to-head clinical analysis: BACTOCILL versus PROBAMPACIN.
Peer-Reviewed Evidence
Head-to-head clinical analysis: BACTOCILL versus PROBAMPACIN.
BACTOCILL vs PROBAMPACIN
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
BACTOCILL (nafcillin) is a penicillinase-resistant penicillin that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), thereby inhibiting transpeptidation and autolysin inhibitors. Active against Staphylococcus aureus and other gram-positive bacteria.
PROBAMPACIN is a synthetic aminoglycoside antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, causing misreading of mRNA and preventing translocation of peptidyl-tRNA from the A-site to the P-site.
250-500 mg orally every 6 hours or 1-2 g intravenously every 4-6 hours
100 mg IV every 12 hours over 30 minutes.
None Documented
None Documented
0.5-0.8 hours; prolonged to 2-4 hours in severe renal impairment
4.5 hours (prolonged to 12-18 hours in severe renal impairment)
Renal: 60-70% unchanged; biliary: 20-30% as active metabolite; fecal: 5-10%
Renal: 70% unchanged; biliary/fecal: 20% as metabolites; 10% other
Category C
Category C
Penicillin Antibiotic
Penicillin Antibiotic