Comparative Pharmacology
Head-to-head clinical analysis: BENTYL PRESERVATIVE FREE versus HICON.
Peer-Reviewed Evidence
Head-to-head clinical analysis: BENTYL PRESERVATIVE FREE versus HICON.
BENTYL PRESERVATIVE FREE vs HICON
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Dicyclomine is a muscarinic acetylcholine receptor antagonist (anticholinergic) that inhibits the action of acetylcholine on structures innervated by postganglionic parasympathetic nerves. It reduces smooth muscle spasm in the gastrointestinal tract by blocking M1, M2, and M3 receptors, with a predominant effect on M3 receptors in the gut.
Unknown; possibly involves modulation of hypothalamic thermoregulatory center.
20 mg orally three times daily; may increase to 40 mg three times daily if tolerated.
HICON (norepinephrine) 0.05-0.5 mcg/kg/min IV continuous infusion, titrated to blood pressure.
None Documented
None Documented
Terminal elimination half-life: 1.9–3.3 hours (in healthy adults). Clinically, short half-life necessitates frequent dosing for sustained effect.
Terminal half-life: 12-18 hours; prolonged to 24-36 hours in renal impairment (CrCl <30 mL/min)
Renal: ~50% (mostly as metabolites), Biliary/Fecal: ~40% (as unchanged drug and metabolites), minor via enterohepatic circulation.
Renal: 70% as unchanged drug; biliary/fecal: 25% as metabolites; 5% other
Category C
Category C
Anticholinergic
Anticholinergic