Comparative Pharmacology
Head-to-head clinical analysis: BICILLIN C R 900 300 versus PENICILLIN.
Peer-Reviewed Evidence
Head-to-head clinical analysis: BICILLIN C R 900 300 versus PENICILLIN.
BICILLIN C-R 900/300 vs PENICILLIN
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Penicillin G benzathine and penicillin G procaine are beta-lactam antibiotics that inhibit bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), disrupting peptidoglycan cross-linking, leading to cell lysis via autolytic enzymes. Synergistic action covers both susceptible Gram-positive cocci (e.g., Streptococcus pyogenes) and some Gram-negative cocci (e.g., Neisseria spp.).
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting transpeptidation and autolysin activation, leading to cell lysis.
Intramuscular injection: 1.2 mL (900,000 units penicillin G benzathine and 300,000 units penicillin G procaine) every 48 hours for 3 doses; for severe infections, up to 2.4 mL (1,800,000/600,000 units) as a single dose.
Penicillin G: 2-4 million units IV every 4-6 hours; Penicillin V: 250-500 mg orally every 6 hours for mild to moderate infections.
None Documented
None Documented
Clinical Note
moderateBenzylpenicillin + Teriflunomide
"The serum concentration of Teriflunomide can be increased when it is combined with Benzylpenicillin."
Clinical Note
moderateBenzylpenicillin + Acemetacin
"Benzylpenicillin may decrease the excretion rate of Acemetacin which could result in a higher serum level."
Clinical Note
moderateProcaine benzylpenicillin + Acemetacin
"Procaine benzylpenicillin may decrease the excretion rate of Acemetacin which could result in a higher serum level."
Clinical Note
moderate0.5-1 hour for penicillin G; prolonged to 3-6 hours in renal impairment. Procaine component has no significant effect on elimination half-life
0.5-1.0 hours in normal renal function; prolonged to 7-10 hours in anuria. Dose adjustment required in renal impairment.
Renal: 60-90% as unchanged drug; biliary/fecal: minor (less than 10%)
Primarily renal (60-80% unchanged via glomerular filtration and tubular secretion); biliary/fecal excretion accounts for 10-20%.
Category C
Category C
Penicillin Antibiotic
Penicillin Antibiotic
Phenoxymethylpenicillin + Acemetacin
"Phenoxymethylpenicillin may decrease the excretion rate of Acemetacin which could result in a higher serum level."