Comparative Pharmacology
Head-to-head clinical analysis: BILTRICIDE versus PRAZIQUANTEL.
Peer-Reviewed Evidence
Head-to-head clinical analysis: BILTRICIDE versus PRAZIQUANTEL.
BILTRICIDE vs PRAZIQUANTEL
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Praziquantel increases the permeability of cell membranes to calcium ions in susceptible schistosomes and other trematodes, causing sustained contraction and paralysis of the worm musculature, leading to detachment from blood vessel walls and eventual death.
Praziquantel increases the permeability of schistosome cell membranes to calcium ions, causing severe contraction and paralysis of the worm musculature, leading to dislodgment and death.
60 mg/kg/day orally in 3 divided doses (20 mg/kg/dose) for 1 day.
20 mg/kg orally three times daily for 1 day for schistosomiasis; 25 mg/kg orally three times daily for 1 day for clonorchiasis and opisthorchiasis; 5-10 mg/kg orally single dose for taeniasis; 15-25 mg/kg orally single dose for hymenolepiasis; 25 mg/kg orally three times daily for 1 day for paragonimiasis, fasciolopsiasis, and heterophyiasis.
None Documented
None Documented
Clinical Note
moderatePraziquantel + Tenofovir disoproxil
"The metabolism of Tenofovir disoproxil can be decreased when combined with Praziquantel."
Clinical Note
moderatePraziquantel + Sulfisoxazole
"The metabolism of Sulfisoxazole can be decreased when combined with Praziquantel."
Clinical Note
moderatePraziquantel + Erythromycin
"The metabolism of Erythromycin can be decreased when combined with Praziquantel."
Clinical Note
moderatePraziquantel + Cyclosporine
Terminal elimination half-life is approximately 0.8-1.5 hours for praziquantel; clinical significance: short half-life necessitates multiple dosing for sustained antiparasitic effect.
Terminal elimination half-life is 1-1.5 hours for praziquantel; 4-6 hours for its main metabolite (4-hydroxypraziquantel). Half-life prolonged in patients with severe hepatic impairment.
Renal excretion accounts for approximately 80-90% of elimination, primarily as metabolites; biliary/fecal excretion is minor (<10%).
Primarily renal: approximately 80% of metabolites excreted in urine (unchanged drug <0.1%); fecal excretion accounts for about 15%.
Category C
Category A/B
Anthelmintic
Anthelmintic
"The metabolism of Cyclosporine can be decreased when combined with Praziquantel."