Comparative Pharmacology
Head-to-head clinical analysis: CHG SCRUB versus PHISOHEX.
Peer-Reviewed Evidence
Head-to-head clinical analysis: CHG SCRUB versus PHISOHEX.
CHG SCRUB vs PHISOHEX
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Chlorhexidine gluconate disrupts bacterial cell membranes, leading to leakage of intracellular contents and cell death. It also binds to proteins and inhibits bacterial enzymes.
Disrupts bacterial cell wall synthesis by binding to the bacterial ribosome and inhibiting protein synthesis; also has surfactant properties that disrupt bacterial cell membrane integrity.
Apply 5 mL to wet skin, scrub for 2 minutes, rinse thoroughly. Use undiluted.
Apply topically as a 3% emulsion to affected area, rinse thoroughly; typically used 1-2 times daily for up to 10 days.
None Documented
None Documented
Approximately 2 hours (terminal); prolonged in renal impairment.
Terminal elimination half-life approximately 6-7 hours in adults with normal renal function. Prolonged in renal impairment (up to 20 hours) due to reduced clearance of active metabolite (pentachlorophenol).
Primarily renal (90% unchanged); <5% biliary/fecal.
Renal (biliary/fecal negligible). Up to 10% of dose excreted unchanged in urine; remainder as metabolites (glucuronide and sulfate conjugates).
Category C
Category C
Antiseptic
Antiseptic