Comparative Pharmacology
Head-to-head clinical analysis: CHLORAMPHENICOL versus COR OTICIN.
Peer-Reviewed Evidence
Head-to-head clinical analysis: CHLORAMPHENICOL versus COR OTICIN.
CHLORAMPHENICOL vs COR-OTICIN
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation.
COR-OTICIN is a combination product containing hydrocortisone (a corticosteroid with anti-inflammatory and immunosuppressive properties) and neomycin (an aminoglycoside antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit) and polymyxin B (a polymyxin antibiotic that disrupts bacterial cell membrane permeability).
50-100 mg/kg/day IV divided every 6 hours (not to exceed 4 g/day); for susceptible severe infections, 12.5-25 mg/kg IV every 6 hours.
1-2 drops in each affected ear twice daily for 7 days.
None Documented
None Documented
Clinical Note
moderateChloramphenicol + Fluconazole
"The metabolism of Fluconazole can be decreased when combined with Chloramphenicol."
Clinical Note
moderateChloramphenicol + Clotrimazole
"The metabolism of Clotrimazole can be decreased when combined with Chloramphenicol."
Clinical Note
moderateChloramphenicol + Ketoconazole
"The metabolism of Ketoconazole can be decreased when combined with Chloramphenicol."
Clinical Note
moderateChloramphenicol + Ticlopidine
1.5-4.0 hours in adults; prolonged to 3-7 hours in neonates and up to 24 hours in severe hepatic impairment
Terminal half-life 4-6 hours; prolonged in renal impairment (up to 12-15 hours)
~90% renal (5-10% unchanged; remainder as inactive glucuronide), ~10% biliary/fecal
Renal (60-80% unchanged), fecal/biliary (5-10%)
Category D/X
Category C
Antibiotic
Topical Corticosteroid + Antibiotic
"The metabolism of Ticlopidine can be decreased when combined with Chloramphenicol."