Comparative Pharmacology
Head-to-head clinical analysis: CHLORTHALIDONE versus HYDRO D.
Peer-Reviewed Evidence
Head-to-head clinical analysis: CHLORTHALIDONE versus HYDRO D.
CHLORTHALIDONE vs HYDRO-D
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Thiazide-like diuretic; inhibits sodium-chloride cotransporter in distal convoluted tubule, increasing excretion of sodium, chloride, and water. Also lowers peripheral vascular resistance.
Thiazide diuretic that inhibits the sodium-chloride symporter (NCC) in the distal convoluted tubule, reducing sodium and water reabsorption and increasing potassium excretion.
Oral: 25-100 mg once daily; initial dose 25 mg once daily; may increase to 50-100 mg once daily based on response.
25-100 mg orally once daily in the morning.
None Documented
None Documented
Terminal half-life 40-60 hours (range 35-70h); prolonged in renal impairment
Clinical Note
moderateChlorthalidone + Digoxin
"The risk or severity of adverse effects can be increased when Chlorthalidone is combined with Digoxin."
Clinical Note
moderateChlorthalidone + Digitoxin
"The risk or severity of adverse effects can be increased when Chlorthalidone is combined with Digitoxin."
Clinical Note
moderateChlorthalidone + Deslanoside
"The risk or severity of adverse effects can be increased when Chlorthalidone is combined with Deslanoside."
Clinical Note
moderateTerminal elimination half-life: 5.6 to 15 hours; prolonged in renal impairment and in patients with heart failure.
Renal: 50-65% unchanged; biliary/fecal: minimal (<5%)
Renal: approximately 50% as unchanged drug; biliary/fecal: approximately 50% as metabolites and minor unchanged drug.
Category C
Category C
Thiazide Diuretic
Thiazide Diuretic
Chlorthalidone + Acetyldigitoxin
"The risk or severity of adverse effects can be increased when Chlorthalidone is combined with Acetyldigitoxin."