Comparative Pharmacology
Head-to-head clinical analysis: CHLORTHALIDONE versus METAHYDRIN.
Peer-Reviewed Evidence
Head-to-head clinical analysis: CHLORTHALIDONE versus METAHYDRIN.
CHLORTHALIDONE vs METAHYDRIN
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Thiazide-like diuretic; inhibits sodium-chloride cotransporter in distal convoluted tubule, increasing excretion of sodium, chloride, and water. Also lowers peripheral vascular resistance.
Metahydrin (trichlormethiazide) is a thiazide diuretic that inhibits the sodium-chloride symporter (NCC) in the distal convoluted tubule of the nephron, reducing sodium and chloride reabsorption and increasing excretion of water, sodium, chloride, and potassium.
Oral: 25-100 mg once daily; initial dose 25 mg once daily; may increase to 50-100 mg once daily based on response.
Oral, 50-100 mg once daily. Maximum 200 mg/day.
None Documented
None Documented
Terminal half-life 40-60 hours (range 35-70h); prolonged in renal impairment
Clinical Note
moderateChlorthalidone + Digoxin
"The risk or severity of adverse effects can be increased when Chlorthalidone is combined with Digoxin."
Clinical Note
moderateChlorthalidone + Digitoxin
"The risk or severity of adverse effects can be increased when Chlorthalidone is combined with Digitoxin."
Clinical Note
moderateChlorthalidone + Deslanoside
"The risk or severity of adverse effects can be increased when Chlorthalidone is combined with Deslanoside."
Clinical Note
moderate18-30 hours (clinically relevant for once-daily dosing in hypertension; prolonged in renal impairment)
Renal: 50-65% unchanged; biliary/fecal: minimal (<5%)
Renal: 30% (fecal: 70% as unabsorbed drug, primarily biliary elimination; <1% unchanged in urine)
Category C
Category C
Thiazide Diuretic
Thiazide Diuretic
Chlorthalidone + Acetyldigitoxin
"The risk or severity of adverse effects can be increased when Chlorthalidone is combined with Acetyldigitoxin."