Comparative Pharmacology
Head-to-head clinical analysis: CLINIMIX E 5 35 SULFITE FREE W ELECT IN DEXTROSE 35 W CALCIUM IN PLASTIC CONTAINER versus TRAVASOL 4 25 IN DEXTROSE 5 IN PLASTIC CONTAINER.
Peer-Reviewed Evidence
Head-to-head clinical analysis: CLINIMIX E 5 35 SULFITE FREE W ELECT IN DEXTROSE 35 W CALCIUM IN PLASTIC CONTAINER versus TRAVASOL 4 25 IN DEXTROSE 5 IN PLASTIC CONTAINER.
CLINIMIX E 5/35 SULFITE FREE W/ ELECT IN DEXTROSE 35% W/ CALCIUM IN PLASTIC CONTAINER vs TRAVASOL 4.25% IN DEXTROSE 5% IN PLASTIC CONTAINER
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Electrolyte and amino acid supplementation to maintain or restore fluid balance, provide calories from dextrose, and supply essential amino acids for protein synthesis; calcium and other electrolytes support physiological functions.
Travasol 4.25% in dextrose 5% is a parenteral nutrition solution providing amino acids and carbohydrates. Amino acids serve as substrates for protein synthesis and other metabolic processes, while dextrose provides a source of glucose for energy. The combination supports tissue repair, growth, and maintenance.
Intravenous infusion at a rate determined by clinical condition and metabolic requirements. Typical adult initial rate: 100 mL/hr, adjusted based on glucose tolerance and fluid status.
Intravenous infusion: 500-2000 mL per day as a source of amino acids and calories, adjusted based on metabolic needs and clinical response. Typical adult dose is 1.5-2.0 g/kg/day of amino acids (equivalent to 35-47 mL/kg/day of TRAVASOL 4.25% IN DEXTROSE 5%) administered via central or peripheral line.
None Documented
None Documented
Not applicable as a single entity; amino acids have half-lives ranging from minutes to hours depending on individual amino acid metabolism. Dextrose has a half-life of about 1-2 hours in fasting state, but this formulation is for continuous infusion, so elimination is constant.
Not applicable as a combined product; amino acids have half-lives of minutes to hours depending on individual amino acid, and dextrose has a half-life of ~15-20 minutes under normal glucose homeostasis.
Renal excretion of amino acids and dextrose metabolites; no significant biliary or fecal elimination. Unused amino acids are deaminated and excreted as urea in urine (approximately 80-90% of nitrogen load). Electrolytes are excreted renally.
Travasol 4.25% in dextrose 5% is a parenteral nutrition solution; the amino acids are metabolized and the nitrogen is excreted primarily in urine as urea (≥90%). Dextrose is metabolized to CO2 and water, with minimal biliary or fecal excretion.
Category C
Category C
Parenteral Nutrition Solution
Parenteral Nutrition Solution