Comparative Pharmacology
Head-to-head clinical analysis: COLESTID versus FLAVORED COLESTID.
Peer-Reviewed Evidence
Head-to-head clinical analysis: COLESTID versus FLAVORED COLESTID.
COLESTID vs FLAVORED COLESTID
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Binds bile acids in the intestine, forming an insoluble complex that is excreted in the feces, thereby increasing fecal loss of bile acids and reducing enterohepatic circulation of bile salts. This leads to increased hepatic conversion of cholesterol to bile acids, reduction in hepatic cholesterol stores, and decreased plasma LDL cholesterol levels.
Colestid (colestipol) is a bile acid sequestrant. It binds bile acids in the intestine, forming an insoluble complex that is excreted in feces. This reduces enterohepatic circulation of bile acids, leading to increased hepatic conversion of cholesterol to bile acids, thereby lowering serum low-density lipoprotein (LDL) cholesterol levels.
5-10 g orally once or twice daily, maximum 30 g/day.
5-30 grams orally daily, divided into 2-4 doses, starting at 5 grams once daily and increasing by 5 grams every 4-7 days as tolerated; taken with meals and mixed with at least 4-8 oz of liquid per dose.
None Documented
None Documented
Not applicable due to non-systemic action; local gastrointestinal half-life not clinically defined
Not applicable due to non-absorbable resin; systemic absorption is negligible. Terminal half-life not defined.
Primarily fecal (≥95%) as unchanged drug; minimal renal excretion (<5%)
Primarily fecal as insoluble complex (90-95%); <5% renal as glucuronide conjugate; minimal biliary elimination.
Category C
Category C
Bile Acid Sequestrant
Bile Acid Sequestrant