Comparative Pharmacology
Head-to-head clinical analysis: COR OTICIN versus FLUTEX.
Peer-Reviewed Evidence
Head-to-head clinical analysis: COR OTICIN versus FLUTEX.
COR-OTICIN vs FLUTEX
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
COR-OTICIN is a combination product containing hydrocortisone (a corticosteroid with anti-inflammatory and immunosuppressive properties) and neomycin (an aminoglycoside antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit) and polymyxin B (a polymyxin antibiotic that disrupts bacterial cell membrane permeability).
Flutamide is a nonsteroidal antiandrogen that competitively inhibits the binding of dihydrotestosterone (DHT) to androgen receptors in target tissues, thereby blocking the androgenic effects.
1-2 drops in each affected ear twice daily for 7 days.
50 mg orally once daily
None Documented
None Documented
Terminal half-life 4-6 hours; prolonged in renal impairment (up to 12-15 hours)
Terminal elimination half-life: 24–36 hours, permitting once-daily dosing in chronic therapy
Renal (60-80% unchanged), fecal/biliary (5-10%)
Renal: ~70% (50% unchanged, 20% as metabolites); Biliary/fecal: ~30%
Category C
Category C
Topical Corticosteroid + Antibiotic
Topical Corticosteroid