Comparative Pharmacology
Head-to-head clinical analysis: CYCLOCORT versus HC 1.
Peer-Reviewed Evidence
Head-to-head clinical analysis: CYCLOCORT versus HC 1.
CYCLOCORT vs HC #1
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Topical corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive actions. Suppresses cytokine production, inhibits phospholipase A2, and reduces prostaglandin synthesis.
Unknown
Apply a thin film topically to affected area twice daily (morning and evening). Not for ophthalmic use.
Hydrocortisone: 100-200 mg IV as initial dose, then 50-100 mg IV every 6 hours, or 0.18 mg/kg/h IV continuous infusion.
None Documented
None Documented
3.5 hours (terminal); clinical effect duration longer due to tissue binding.
2–4 hours (terminal); prolonged in renal impairment.
Primarily hepatic metabolism; inactive metabolites excreted renally (<1% unchanged) and in feces (biliary).
Renal: 90% as unchanged drug; fecal: 10%.
Category C
Category C
Topical Corticosteroid
Topical Corticosteroid