Comparative Pharmacology
Head-to-head clinical analysis: DIALYTE W DEXTROSE 1 5 IN PLASTIC CONTAINER versus DIANEAL 137 W DEXTROSE 1 5 IN PLASTIC CONTAINER.
Peer-Reviewed Evidence
Head-to-head clinical analysis: DIALYTE W DEXTROSE 1 5 IN PLASTIC CONTAINER versus DIANEAL 137 W DEXTROSE 1 5 IN PLASTIC CONTAINER.
DIALYTE W/ DEXTROSE 1.5% IN PLASTIC CONTAINER vs DIANEAL 137 W/ DEXTROSE 1.5% IN PLASTIC CONTAINER
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Removes uremic toxins, corrects electrolyte imbalances, and removes excess fluid via peritoneal dialysis.
DIANEAL 137 with 1.5% dextrose is a peritoneal dialysis solution that removes waste products and excess fluid from the blood by creating a concentration gradient across the peritoneal membrane via diffusion and ultrafiltration. Dextrose acts as an osmotic agent to drive fluid removal.
Intraperitoneal administration: 2 liters per exchange, 4 exchanges per day (typical for continuous ambulatory peritoneal dialysis).
Intraperitoneal administration: 2 liters per exchange, typically 4 exchanges per day for continuous ambulatory peritoneal dialysis (CAPD).
None Documented
None Documented
Dextrose: ~2-2.5 hours (glucose turnover); electrolytes and lactate have rapid distribution and elimination half-lives of minutes to hours. In renal impairment, half-life of dialyzed solutes may be prolonged.
Not applicable for dextrose as it is an endogenous substance. Exogenous dextrose in peritoneal dialysis is rapidly metabolized; plasma glucose half-life is approximately 1-2 hours after absorption, but this varies with metabolic state.
Primarily renal; glucose and electrolytes are reabsorbed or excreted by kidneys. For IP administration, dialysis fluid components (e.g., dextrose, sodium, chloride, lactate) are absorbed and then eliminated via renal and metabolic pathways: ~60% of absorbed dextrose is metabolized, remainder excreted renally; electrolytes are excreted renally; lactate is metabolized to bicarbonate.
Dianeal 137 with 1.5% dextrose is a peritoneal dialysis solution. Dextrose is metabolized systemically; glucose is absorbed via peritoneal route and undergoes endogenous metabolism. Icodextrin (if applicable) is metabolized to maltose and excreted renally, but for this standard solution, elimination is primarily via metabolism to CO2 and water; less than 5% excreted unchanged in urine. No biliary or fecal elimination of intact dextrose.
Category C
Category C
Peritoneal Dialysis Solution
Peritoneal Dialysis Solution