Comparative Pharmacology
Head-to-head clinical analysis: DIANEAL 137 W DEXTROSE 1 5 IN PLASTIC CONTAINER versus DIANEAL LOW CALCIUM W DEXTROSE 2 5 IN PLASTIC CONTAINER.
Peer-Reviewed Evidence
Head-to-head clinical analysis: DIANEAL 137 W DEXTROSE 1 5 IN PLASTIC CONTAINER versus DIANEAL LOW CALCIUM W DEXTROSE 2 5 IN PLASTIC CONTAINER.
DIANEAL 137 W/ DEXTROSE 1.5% IN PLASTIC CONTAINER vs DIANEAL LOW CALCIUM W/DEXTROSE 2.5% IN PLASTIC CONTAINER
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
DIANEAL 137 with 1.5% dextrose is a peritoneal dialysis solution that removes waste products and excess fluid from the blood by creating a concentration gradient across the peritoneal membrane via diffusion and ultrafiltration. Dextrose acts as an osmotic agent to drive fluid removal.
The dextrose component provides osmotic pressure for peritoneal dialysis, promoting ultrafiltration of fluid and removal of solutes. Calcium and other electrolytes maintain physiologic balance.
Intraperitoneal administration: 2 liters per exchange, typically 4 exchanges per day for continuous ambulatory peritoneal dialysis (CAPD).
Intraperitoneal: Continuous ambulatory peritoneal dialysis (CAPD): 2-2.5 L per exchange, 4-5 exchanges per day; Continuous cyclic peritoneal dialysis (CCPD): 2-2.5 L per exchange, 3-5 nocturnal exchanges plus one daytime dwell.
None Documented
None Documented
Not applicable for dextrose as it is an endogenous substance. Exogenous dextrose in peritoneal dialysis is rapidly metabolized; plasma glucose half-life is approximately 1-2 hours after absorption, but this varies with metabolic state.
Not applicable as a solution; glucose half-life ~20-30 min in circulation; clinical effect duration corresponds to dwell time (4-6 hours for standard exchange)
Dianeal 137 with 1.5% dextrose is a peritoneal dialysis solution. Dextrose is metabolized systemically; glucose is absorbed via peritoneal route and undergoes endogenous metabolism. Icodextrin (if applicable) is metabolized to maltose and excreted renally, but for this standard solution, elimination is primarily via metabolism to CO2 and water; less than 5% excreted unchanged in urine. No biliary or fecal elimination of intact dextrose.
Primarily eliminated via peritoneal dialysis; glucose is metabolized systemically and excreted as CO2 and water; <5% renal excretion of metabolites
Category C
Category C
Peritoneal Dialysis Solution
Peritoneal Dialysis Solution