Comparative Pharmacology
Head-to-head clinical analysis: DIANEAL 137 W DEXTROSE 1 5 IN PLASTIC CONTAINER versus INPERSOL LC LM W DEXTROSE 4 25 IN PLASTIC CONTAINER.
Peer-Reviewed Evidence
Head-to-head clinical analysis: DIANEAL 137 W DEXTROSE 1 5 IN PLASTIC CONTAINER versus INPERSOL LC LM W DEXTROSE 4 25 IN PLASTIC CONTAINER.
DIANEAL 137 W/ DEXTROSE 1.5% IN PLASTIC CONTAINER vs INPERSOL-LC/LM W/ DEXTROSE 4.25% IN PLASTIC CONTAINER
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
DIANEAL 137 with 1.5% dextrose is a peritoneal dialysis solution that removes waste products and excess fluid from the blood by creating a concentration gradient across the peritoneal membrane via diffusion and ultrafiltration. Dextrose acts as an osmotic agent to drive fluid removal.
Removes uremic toxins and excess fluid via diffusion and ultrafiltration across the peritoneal membrane.
Intraperitoneal administration: 2 liters per exchange, typically 4 exchanges per day for continuous ambulatory peritoneal dialysis (CAPD).
Intraperitoneal: For continuous ambulatory peritoneal dialysis (CAPD), instill 2 liters of 4.25% dextrose solution into the peritoneal cavity four times daily (4 exchanges/day). For automated peritoneal dialysis (APD), use 2-3 liters per cycle with multiple cycles overnight. Adjust volume and frequency based on patient's fluid and electrolyte status.
None Documented
None Documented
Not applicable for dextrose as it is an endogenous substance. Exogenous dextrose in peritoneal dialysis is rapidly metabolized; plasma glucose half-life is approximately 1-2 hours after absorption, but this varies with metabolic state.
Dextrose: approximately 1-2 hours (terminal half-life of glucose in plasma); clinical context: continuous peritoneal dialysis (CAPD) maintains steady-state glucose levels.
Dianeal 137 with 1.5% dextrose is a peritoneal dialysis solution. Dextrose is metabolized systemically; glucose is absorbed via peritoneal route and undergoes endogenous metabolism. Icodextrin (if applicable) is metabolized to maltose and excreted renally, but for this standard solution, elimination is primarily via metabolism to CO2 and water; less than 5% excreted unchanged in urine. No biliary or fecal elimination of intact dextrose.
Renal: 80-90% of dextrose metabolites (CO2 and H2O) are excreted via lungs and kidneys; electrolytes and water are eliminated renally. Biliary/fecal: minimal (<5%).
Category C
Category C
Peritoneal Dialysis Solution
Peritoneal Dialysis Solution