Comparative Pharmacology
Head-to-head clinical analysis: DURACILLIN A S versus KLEBCIL.
Peer-Reviewed Evidence
Head-to-head clinical analysis: DURACILLIN A S versus KLEBCIL.
DURACILLIN A.S. vs KLEBCIL
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Penicillin G procaine is a beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death.
Klebcillin is a beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting transpeptidase activity, and activating autolytic enzymes.
600,000 units intramuscularly once daily; or 1.2 million units intramuscularly every 12 hours for severe infections.
KLEBCIL (ceftazidime-avibactam) 2.5 g (ceftazidime 2 g + avibactam 0.5 g) IV every 8 hours infused over 2 hours.
None Documented
None Documented
0.5-1 hour in adults with normal renal function; prolonged to 7-10 hours in end-stage renal disease
2-3 hours (prolonged to 30-60 hours in severe renal impairment; adjust dosing)
Primarily renal (60-90% unchanged via tubular secretion and glomerular filtration); minor biliary/fecal elimination (<10%)
Primarily renal (70-80% unchanged); minor biliary/fecal (15-20%)
Category C
Category C
Penicillin Antibiotic
Penicillin Antibiotic