Comparative Pharmacology
Head-to-head clinical analysis: DURACILLIN A S versus OXACILLIN SODIUM.
Peer-Reviewed Evidence
Head-to-head clinical analysis: DURACILLIN A S versus OXACILLIN SODIUM.
DURACILLIN A.S. vs OXACILLIN SODIUM
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Penicillin G procaine is a beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death.
Oxacillin is a penicillinase-resistant beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), thereby blocking the transpeptidation step in peptidoglycan cross-linking. It is resistant to staphylococcal beta-lactamase.
600,000 units intramuscularly once daily; or 1.2 million units intramuscularly every 12 hours for severe infections.
1-2 grams IV every 4-6 hours.
None Documented
None Documented
0.5-1 hour in adults with normal renal function; prolonged to 7-10 hours in end-stage renal disease
0.3-0.8 hours in adults with normal renal function; prolonged to 1-2 hours in neonates and 2-5 hours in patients with severe renal impairment (CrCl <10 mL/min)
Primarily renal (60-90% unchanged via tubular secretion and glomerular filtration); minor biliary/fecal elimination (<10%)
Renal (70-80% unchanged by tubular secretion and glomerular filtration); biliary (minor, approximately 10%)
Category C
Category A/B
Penicillin Antibiotic
Penicillin Antibiotic