Comparative Pharmacology
Head-to-head clinical analysis: DURACILLIN A S versus PENICILLIN G POTASSIUM.
Peer-Reviewed Evidence
Head-to-head clinical analysis: DURACILLIN A S versus PENICILLIN G POTASSIUM.
DURACILLIN A.S. vs PENICILLIN G POTASSIUM
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Penicillin G procaine is a beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death.
Bactericidal: inhibits transpeptidases (penicillin-binding proteins) involved in bacterial cell wall synthesis, leading to cell lysis.
600,000 units intramuscularly once daily; or 1.2 million units intramuscularly every 12 hours for severe infections.
1-4 million units IV every 4-6 hours; maximum 24 million units/day
None Documented
None Documented
0.5-1 hour in adults with normal renal function; prolonged to 7-10 hours in end-stage renal disease
0.5-1 hour in normal renal function; prolonged to 3-10 hours in anuria/end-stage renal disease.
Primarily renal (60-90% unchanged via tubular secretion and glomerular filtration); minor biliary/fecal elimination (<10%)
Renal (60-90% as unchanged drug via tubular secretion and glomerular filtration); biliary (minor, <10%); fecal (minimal, <5%).
Category C
Category A/B
Penicillin Antibiotic
Penicillin Antibiotic